Hypersensitivity Pneumonitis, Nasal Mucosal Disorder
Conditions
Keywords
hypersensitivity pneumonitis, nasal mucosa histopaholgical changes
Brief summary
Background:Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops after inhalation of organic or inorganic antigens in susceptible individuals. The nasal mucosa is constantly exposed to these antigens that can irritate the respiratory mucosa. Objectives: to assess the burden of sinonasal symptoms in HP patients and to evaluate the nasal histopathology in those patients.
Interventions
PROCEDUREnasal endoscopy
nasal endoscopy and mucosal biopsy
Sponsors
Cairo University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
29 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* all patients with clinical and radiological features of HP
Exclusion criteria
* respiratory failure * patients on anticoagulants
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| percentage of patients with HP developed nasal mucosa granuloma and lymphocytic infiltrations as detected by nasal endoscopy | 6 months | nasal endoscopy and nasal mucosa biopsy was done for all patients to measure the % of patients with nasal granuloma and lymphocytic infiltrations |
Countries
Egypt
Outcome results
None listed