Prospective Validation of an Acute Pulmonary Embolism Severity and Prognosis Prediction Model

Multicenter Prospective Validation and Extension of the 'PUMCH' Acute Pulmonary Embolism Severity and Prognosis Prediction Model

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05723003

Enrollment

4000

Registered

2023-02-10

Start date

2023-02-01

Completion date

2025-10-30

Last updated

2023-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Embolism

Keywords

Pulmonary Embolism, Prognosis assessment model

Brief summary

The purpose of this study is to prospectively validate the first PUMCH model for acute PE severity and prognosis prediction based on multi-center data constructed in the pre-project period based on national population data, and to optimize the PUMCH model based on artificial intelligence clustering algorithm.

Detailed description

Patients with pulmonary embolism and aged 18 years or older were enrolled in this study.Patient demographic characteristics(age, sex, department, diagnosis), basic vital signs, symptoms at their admissions (hemoptysis, dyspnea, chest pain, syncope, laboratory examinations (blood lab routines, blood gas, liver and kidney function, myocardial marker), and imaging examinations (vascular ultrasonography, computed tomographic angiography, echocardiography, chest CT,CTPA, pulmonary perfusion imaging, pulmonary angiography, PET/CT) were prospectively collected. Patients were followed up every 1/3/6 months to obtain survival outcomes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* age ≥ 18 years * Inpatients with acute PTE diagnosed by imaging (CTPA, enhanced CT, V/Q imaging suggesting a high probability of PE, pulmonary angiography, MRPA) containing any of the following conditions. 1. primary acute PTE combined with or without DVT 2. recurrent acute PTE with a history of previous PTE or DVT * signed informed consent form

Exclusion criteria

* blinded to any diagnostic or therapeutic test (VTE or other conditions) * unable to complete follow-up (due to cognitive or behavioral limitations, etc.)

Design outcomes

Primary

Measure	Time frame	Description
All-cause mortality	through study completion, an average of 1 year	all-cause mortality 30 days after diagnosis of acute symptomatic PE.

Countries

China

Contacts

Primary ContactJuhong Shi, M.D

shijh@pumch.cn+8613701178492

Backup ContactMin Peng, M.D

pengmin@pumch.cn+8613581888792

Outcome results