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Effects of Hardaliye, a Fermented Grape Drink, on Oxidative Stress, Lipid Profile and Blood Pressure in Young Footballers

Effects of Hardaliye, a Fermented Grape Drink, on Oxidative Stress, Lipid Profile and Blood Pressure in Young Footballers: A Randomised Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05722600
Enrollment
36
Registered
2023-02-10
Start date
2022-02-01
Completion date
2022-03-08
Last updated
2023-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diet, Healthy, Antioxidative Stress

Brief summary

In the present study, the authors aimed to investigate the effects of hardaliye (grape juice) consumption on oxidative stress parameters, lipid profile and blood pressure in young football players.

Interventions

Hardaliye (grape juice) is a fermented, traditional non-alcoholic beverage made from fresh grapes. It is mainly produced by the fermentation of grapes, sour cherry leaves and mustard seeds. Hardaliye was purchased from traditional producers in Turkey. Hardaliye Group consumed 250 ml/day of hardaliye (grape juice) for 28 days.

OTHERPlacebo drink

Placebo drink has carbohydrate, energy and sensory properties similar to hardaliye. Placebo Group consumed 250 ml/day of placebo drink

Sponsors

Medipol University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
MALE
Age
15 Years to 24 Years
Healthy volunteers
Yes

Inclusion criteria

* Being a male football player playing in a team in the Elite Development League, * Participating in training with the team at least 5 days a week for 3 months, * Not consuming red wine, grape juice, and/or hardaliye regularly before the study was started, * Those who stayed in the sports facility where catering service was provided for breakfast, lunch and dinner were included in the study.

Exclusion criteria

* With chronic disease, * Smoker, * Those taking antioxidant supplements, * Non-cooperative subjects or unwilling to sign an informed consent and participate in the study.

Design outcomes

Primary

MeasureTime frameDescription
Change in total antioxidant capacity28 daysMeasurement of serum level of total antioxidant capacity (μmol Trolox eq/L).
Change in total oxidation status28 daysMeasurement of serum level of total oxidation status (μmol H2O2 eq/L).
Change in oxidative stress index28 days(Serum level of total oxidation status/serum level of total antioxidant capacity) × 100
Change in lipid parameters28 daysMeasurement of serum levels total cholesterol (mg/dl), HDL-cholesterol (mg/dl), LDL-cholesterol (mg/dl) and triglycerides (mg/dl).
Change in blood pressure28 daysMeasurement of systolic (mm Hg) and diastolic blood pressure (mm Hg)

Secondary

MeasureTime frameDescription
Change in perceived exercise-induced pain28 daysPerceived exercise-induced pain was determined using the 100-mm Visual Analog Scale. 100-mm Visual Analog Scale scores range from 0 (no pain) to 100 (most severe pain). A higher score indicates a higher perceived pain level.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026