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Efficacy of Rectal Indomethacin in Prevention of Post-pancreatectomy Acute Pancreatitis

Efficacy of Rectal Indomethacin in Prevention of Post-pancreatectomy Acute Pancreatitis-A Randomized Controlled Trial

Status
UNKNOWN
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05722548
Enrollment
200
Registered
2023-02-10
Start date
2023-02-01
Completion date
2024-02-01
Last updated
2023-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatectomy

Brief summary

The purpose of this study is to evaluate the efficacy of rectal indomethacin in prevention of post-pancreatectomy acute pancreatitis.

Detailed description

The purpose of this study is to evaluate the efficacy of rectal indomethacin in prevention of post-pancreatectomy acute pancreatitis.

Interventions

DRUGIndomethacin suppository

100mg of Indomethacin Suppository sigle dose at the time of induction of anesthesia

OTHERStandard Medical Treatment

Standard Medical Treatment

Sponsors

Shanghai Jiao Tong University School of Medicine
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

\*All patients planned to undergo pancreatectomy.

Exclusion criteria

* asthma * allergic reactions to NSAIDs * CKD * internal hemorrhoids * anti-platelet medications

Design outcomes

Primary

MeasureTime frame
Post-pancreatectomy Acute Pancreatitis2 weeks after pancreatectomy

Secondary

MeasureTime frame
Pancreatic Fistula30 days after pancreatectomy
Peripancreatic abscess30 days after pancreatectomy
Length of hospital stay30 days after pancreatectomy

Contacts

Primary ContactYingbin Liu, PHD
laoniulyb@163.com+8613918803900

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026