Sarcopenia, Sarcopenic Obesity, Dementia
Conditions
Brief summary
1\. To develop a multiactivity training programme. 2. To explore the effect of this programme on sarcopenia, sarcopenic obesity, cognitive impairment and Parkinson's disease. 3. To compare the effects of the experimental and control treatments on the muscle strength, body composition, physical function performance and quality of life of the elderly.
Interventions
DIETARY_SUPPLEMENTprotein supplementation
protein supplementation for 16 weeks
BEHAVIORALmuscle strength training
muscle strength training for 16 weeks
OTHERusual care
no intervention
Sponsors
Central Taiwan University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
(1) over 60 years old, (2) able to Communicate and follow instructions; (3) Stable condition with sufficient physical strength: able to maintain a seated position in a wheelchair or on the edge of a bed for at least one hour. (4) sarcopenia, sarcopenic obesity, cognitive impairment and Parkinson's disease.
Exclusion criteria
(1) difficulty in standing or walking and obvious musculoskeletal disease, (2) unsuitable for diagnosis by a physician those engaged in sports activities, (3) serious diseases/unstable states, such as severe heart, lung, liver and kidney diseases, severe malignant tumors, severe nutrition poor, severe dementia, (4) more than 180 minutes of exercise per week in the past month, (5) no willingness to participate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Chang in muscle strength from baseline to 16 weeks | Baseline and 16 weeks | pinch, grip and quadriceps strength. A Higher score means a better outcome. |
| Chang in weight of muscle and fat from baseline to 16 weeks | Baseline and 16 weeks | muscle mass(kg), fat mass (kg) |
| Chang in Activities of Daily Living from baseline to 16 weeks | Baseline and 16 weeks | This is a scale of physical function. The range for total score is 0-100. A Higher score means a worse outcome. |
| Chang in Instrumental activities of daily living from baseline to 16 weeks | Baseline and 16 weeks | This is a scale of physical function. The range for total score is 0-24. A Higher score means a better outcome. |
| Chang in Clinical Dementia Rating from baseline to 16 weeks | Baseline and 16 weeks | Mental Function Assessment. The range is 0-3. A Higher score means a worse outcome. |
| Chang in Cornell Scale for Depression in Dementia from baseline to 16 weeks | Baseline and 16 weeks | Mental Function Assessment. The range for total score is 0-38. A Higher score means a worse outcome. |
| Chang in Cohen-Mansfield Agitation Inventory from baseline to 16 weeks | Baseline and 16 weeks | This is a scale of behavior measurement. The range for total is 29-203. A higher score means a worse outcome. |
| Chang in EQ5D from baseline to 16 weeks | Baseline and 16 weeks | This is a scale of quality of life. The range for total is 0-20. A higher score means a worse outcome. |
| Chang in QUALIDEM from baseline to 16 weeks | Baseline and 16 weeks | The scale is a dementia-specific Qol instrument. The range for total score is 0-120. A higher score means a better outcome. |
| Demographic attributes | Baseline | Gender, education, age, married status, religion, medication, diseases, work and height. |
| Chang in PERSONAL WELLBEING INDEX from baseline to 16 weeks | Baseline and 16 weeks | The range for total is 0-80. A higher score means a better outcome. |
| Chang in PERSONAL WELLBEING INDEX intellectual disability from baseline to 16 weeks | Baseline and 16 weeks. | The range for total is 0-70. A higher score means a better outcome. |
| Chang in World Health Organization Quality of Life Instruments (WHOQOL-BREF) from baseline to 16 weeks | Baseline and 16 weeks. | This is a scale of quality of life. The range for total is 26-130. A higher score means a better outcome. |
| Chang in Four-Meter Gait Speed from baseline to 16 weeks | Baseline and 16 weeks. | Measured with seconds. A higher score means a worse outcome. |
Countries
Taiwan
Outcome results
None listed