Chronic Lymphocytic Leukemia, Lymphoproliferative Disorders, Monoclonal B-Cell Lymphocytosis, Premalignant
Conditions
Keywords
lymphoproliferative disorders, Chronic Lymphocytic Leukemia, Monoclonal B-cell Lymphocytosis
Brief summary
This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.
Interventions
OTHERNo intervention
No intervention
Sponsors
Bnai Zion Medical Center
University of Haifa
Study design
Observational model
FAMILY_BASED
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patient inclusion criteria: Patients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study. Criteria for the inclusion of relatives of patients: Relatives must be related by blood to LPD patients or unrelated (for control group). Relatives who signed an informed consent to participate in the study.
Exclusion criteria
* Pregnant women, special populations and those lacking judgment will not be included
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of familial LPD in Israel | 5 years |
| Association between medical history and genetic variants and the risk of familial LPD | 5 years |
| Risk of clinical outcomes among familial LPD and family members | 15 years |
Contacts
Primary ContactGeffen Kleinstern, PhD
Backup ContactTamar Tadmor, MD
Outcome results
None listed