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Patient Tailored Contrast Volume for Preoperative CT Angiography of the Aorta

Patient Tailored Contrast Volume for Preoperative CT Angiography of the Aorta: A Prospective Study Based on Patient Heart Rate and Body Surface Area Differences

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05716568
Enrollment
60
Registered
2023-02-08
Start date
2014-04-30
Completion date
2015-12-31
Last updated
2023-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Aneurysm

Keywords

CT-angiography, Aortic aneurysm, Aortic dissection, Pre-operative, Contrast dose reduction

Brief summary

An in-house calculator was developed to calculate the appropriate contrast dose, rather than standardly administering a 120ml dose. This study aims for a more uniform contrast enhancement in patients by means of adjusting (lowering) contrast dose to patient parameters.

Detailed description

Until now, CT scans in our and many other institutions are being performed with a fixed standard contrast dose specific for every protocol, independent of patient characteristics. However, many if not all patients would benefit from a contrast dose reduction, as long as image quality is not impaired. This is especially beneficial to patients with impaired renal function. For this purpose, we researched previous literature as well as data from previously scanned patients with standard dose, to formulate a contrast dose calculation adapted to patient parameters. An in-house calculator was developed to calculate the optimal contrast dose dependent on patient length, weight and heartrate. A total of 60 CT-scans will be performed and retrospectively collected. Patients are randomly assigned to one of three groups : 1/ Standard dose of 120ml; 2/ Calculated dose (40-150ml) 3/ Calculated dose -50% (20-120ml). In case of reduced kidney function, patients were randomly divided between group 2 and 3 (reduced contrast dose).

Interventions

OTHERContrast dose reduction, CT-angiography

Contrast dose reduction for CT-angiography in pre-operative aorta

Sponsors

Universitaire Ziekenhuizen KU Leuven
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Patients requiring CT-angiography of the aorta as requested by clinician * For aneurysm detection or follow-up * Or for dissection follow-up * Thoraco-abdominal aorta or abdominal aorta

Exclusion criteria

* Contra-indications for contrast administration (severe renal impairment or adverse reactions) * Previously endovascular repair of the aorta * Only thoracic aorta * No informed consent * Contrast injection at 4cc/second not possible

Design outcomes

Primary

MeasureTime frameDescription
Reduction in contrast doseThrough study completion, an average of 1 yearReduction in contrast dose while maintaining image quality

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026