Determine the Effects of Prone Positioning and NO in COVID-19 ARDS by EIT

Determine the Effects of Prone Positioning and Nitric Oxide in Adult COVID-19 Patients With ARDS by Electrical Impedance Tomography

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05715762

Enrollment

Registered

2023-02-08

Start date

2022-12-21

Completion date

2023-12-31

Last updated

2023-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19, Respiratory Distress Syndrome, Adult

Keywords

Respiratory Distress Syndrome, COVID-19

Brief summary

We aims to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography.

Detailed description

The investigators aim to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography (EIT). The EIT assessment is performed in patients ventilated in supine position, supine position with NO inhalation for 1 hour, prone position for 1 hour, prone position for 2 hours with NO inhalation for 1 hour, prone position for 3 hours, prone position for 16 hours, re-supine position for 3 hours. Arterial blood gas (ABG) analysis results, ventilator parameters and hemodynamic parameters are also recorded at each time point.

Interventions

BEHAVIORALprone postion

ventilation at prone positioning

DRUGNO inhalation

NO inhalation at 20 ppm

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Inclusion criteria

* adult patients who have COVID-19-associated acute respiratory distress syndrome

Exclusion criteria

* patients who refuse to participate in the study; unable to use EIT, such as open-chest surgery with chest tube placement; have contraindication for prone positioning, including pregnant, post-abdomen surgery within a week; hypercapnic respiratory failure.

Design outcomes

Primary

Measure	Time frame	Description
oxygenation status	1 day	To evaluate the oxygenation parameters
regional distribution of pulmonary perfusion	1 day	To evaluate the effect of prone positon and NO inhalation on pulmonary blood flow distribution.
regional distribution of pulmonary ventilation	1 day	To evaluate the effect of prone positon and NO inhalation on pulmonary vetilation distribution.

Countries

China

Contacts

Primary ContactMing Zhong, PhD

zhong.ming@zs-hospital.sh.cn021-65642662

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 24, 2026