Menopause Related Conditions
Conditions
Brief summary
This will be a randomized study to determine if animal-based protein-rich food sources can stimulate greater muscle protein turnover and whole-body protein balance and reduce skeletal muscle inflammatory markers in postmenopausal women compared to vegetarian base protein-rich foods.
Detailed description
A randomized cross-sectional controlled trial will be conducted to quantify whole-body and muscle protein turnover and skeletal muscle inflammation following 5-days of consumption of either beef or isonitrogenous plant-based sources of protein in normal/overweight and obese post-menopausal females. A premenopausal normal/overweight group consuming beef containing study meals will also be recruited to serve as a healthy control comparison.
Interventions
OTHERmeals consisting of primarily animal protein sources
an omnivorous diet
OTHERmeals consisting of plant protein sources
an herbivorous diet
Sponsors
University of Arkansas
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Intervention model description
A randomized cross-sectional controlled trial will be conducted to quantify whole-body and muscle protein turnover and skeletal muscle inflammation following 5-days of consumption of either beef or isonitrogenous plant-based sources of protein in normal/overweight and obese post-menopausal females.
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Postmenopausal women ages 50-65 (absence of menstruation for at least 12 months). 2. Premenopausal women ages 35-45 (presence of normal monthly menstruation for the past 12 months). 3. BMI of 20.0 - 34.9 kg/m2. 4. COVID-19 negative and/or asymptomatic
Exclusion criteria
1. Any substantial musculoskeletal injuries/diseases that have limited daily activities in the past month. 2. Unable to stop the use of anti-inflammatory drugs for the week prior to and during study. 3. Diagnosed metabolic or hormonal disease (i.e., renal, cardiovascular, thyroid, polycystic ovary syndrome, or type I/II diabetes mellitus). 4. Currently pregnant. 5. Gave birth or was lactating within previous 12 months. 6. Undergone gastric bypass/bariatric surgery. 7. Clinically significant weight gain or loss (\>5% change) in the last 12 months. 8. Consuming metabolism-altering drugs or medications (i.e., corticosteroids, stimulants, insulin, thyroid medication). 9. Unable or unwilling to suspend anti-clotting medications including aspirin use for 5 days prior to Visit 4. 10. Participating in \>200 minutes/week of vigorous exercise and/or \>4 days/week of resistance training. 11. Unwilling to fast overnight. 12. Surgical menopause. 13. Having undergone hormone replacement therapy in the last 12 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Net change in muscle protein synthesis (% per day). | Study meals are eaten for 5 consecutive days. | Change in net muscle protein synthesis between groups. |
Countries
United States
Outcome results
None listed