OCT Eccentric Fixation and Amblyopia in Children

OCT Eccentric Fixation, Fixation Stability, and Amblyopia in Children

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05714449

Enrollment

Registered

2023-02-06

Start date

2023-01-25

Completion date

2026-01-24

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amblyopia

Keywords

eccentric fixation, amblyopia, patching, foveation therapy, OCT

Brief summary

The objectives of this proposal are to characterize the relationship between OCT eccentric fixation (OCT-EF), fixation eye movement (FEM), macular sensitivity in children with amblyopia.

Detailed description

Aim 1. OCT EF changes with patching treatment at 12 weeks visit. Aim 2. OCT EF changes with foveation therapy.

Interventions

DEVICEeye patch

standard amblyopia treatment

DEVICEAfter-image and MIT trainer

Common clinical training for foveation

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

4 Years to 16 Years

Healthy volunteers

Inclusion criteria

1. children with best-corrected visual acuity (BCVA) of 20/40 (equivalent to 0.3 logMAR) or worse in the amblyopic eye (ranging from 20/40 to 20/400), and interocular difference of BCVA was at least two logMAR lines, 2. ocular causes of amblyopia that were identified as refractive(i.e., anisometropic, strabismus, or strabismic-anisometropic. * Anisometropia included interocular difference of spherical equivalent \>=1D or interocular difference of astigmatism cylinder magnitude \>=1D; * strabismus included those with deviation \>=10PD or good alignment after prior strabismus surgery; * combined type included those who meet the criteria of both anisometropia and strabismus. * For the patching group, we will enroll 15 children with strabismic amblyopia who are prescribed patching treatment. Age: 4-12 years old. * For the foveation therapy group, we will enroll 15 children with strabismic amblyopia who are prescribed foveation therapies. Age: 8-16 years old.

Exclusion criteria

* born before 32 weeks gestational age; * neurologic, developmental, or systemic illnesses known to be associated with ocular pathologies; * congenital or acquired macular pathology.

Design outcomes

Primary

Measure	Time frame	Description
OCT eccentric fixation	12 weeks	eccentric fixation measured with OCT imaging.

Countries

United States

Contacts

Primary ContactJingyun Wang, PhD

jwang@sunyopt.edu2129385759

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026