Resting Energy Expenditure
Conditions
Keywords
Xanthohumol, micellar solubilization, fatty acid oxidation
Brief summary
The aim of this study is to investigate the effects of Xanthohumol on resting energy expenditure and substrate oxidation in healthy women. It is assumed that resting energy expenditure and fatty acid oxidation is higher after Xanthohumol ingestion.
Detailed description
In a crossover design, 16 healthy young women ingest 172 mg micellar solubilized Xanthohumol or placebo in a randomized fashion. During an observational period of 3 hours, the acute effects of Xanthohumol on the resting energy expenditure and substrate oxidation is determined by respiratory gas analysis. An additional 30-minute determination of the resting energy expenditure and substrate oxidation is executed 24 hours after Xanthohumol ingestion. The wash-out period will be 28 days.
Interventions
DIETARY_SUPPLEMENTmicellar solubilized Xanthohumol
single administration of 4 soft gelatine capsules each containing 43 mg micellar solubilized Xanthohumol
DIETARY_SUPPLEMENTPlacebo
single administration of 4 soft gelatine capsules containing only micelles
Sponsors
University of Bonn
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI: 18,5 - 24,9 kg/m2 * metabolically healthy * written consent
Exclusion criteria
* smoking * low or high blood pressure * dyslipidemia * insulin resistance or diabetes mellitus type 1 or type 2 * gastrointestinal diseases (e.g. food intolerances or allergies) * liver, kidney and/or thyroid diseases * hepatitis B or C, HIV Infection * chronic inflammatory diseases * disordered eating * psychological diseases * alcohol and/or drug abuse * use of medication * pregnancy or lactating * participation in another intervention study * irregular menstrual cycle * more than 6 hours of sports per week
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prolonged Effect on Substrate Oxidation | assessed uninterrupted for 30 minutes 24 h post dose | assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent |
| Acute Effect on Resting Energy Expenditure | assessed uninterrupted for 3 hours post dose | calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24 hours |
| Prolonged Effect on Resting Energy Expenditure | assessed uninterrupted for 30 minutes 24 h post dose | calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24hours |
| Acute Effect on Substrate Oxidation | assessed uninterrupted for 3 hours post dose | assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Acute Effect on Blood pressure | 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose | given in millimeter mercury |
| Prolonged Effect on Blood pressure | 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose | given in millimeter mercury |
| Acute Effect on Pulse | 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose | given in beats per minute |
| Prolonged Effect on Pulse | 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose | given in beats per minute |
Countries
Germany
Outcome results
None listed