Pigmentation, Pigmentation Disorder
Conditions
Brief summary
Melasma relapse is almost common after discontinuation of conventional treatment. Recent studies have suggested that photoaging dermis is main pathomechanism of melasma emphasizing stromal targeting therapy. Therefore, we investigated maintenance effect of microneedle radiofrequency (RF) for melasma treatment.
Interventions
DEVICERF Microneedle
Pulsed-type RF device in bipolar mode with 25 non-insulated microneedles every 2 weeks for 6 month
5% hydroquinone, 0.003% tretinoin, and 1% hydrocortisone twice daily for 2 months
Sponsors
Ajou University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Intervention model description
split lesion study
Eligibility
Sex/Gender
FEMALE
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult more than 19 years old * Melasma clinically diagnosed by three dermatologists
Exclusion criteria
* Aesthetic medical procedures in three months prior to the study * Use of topical depigmenting agents in three months prior to the study * Pregnant or lactating
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of modified melasma area severity index score | Every 1 month up to 8 months | Change of modified melasma area severity index score |
| Change of lightness value | Every 1 month up to 8 months | Change of lightness value by a chromometer |
Countries
South Korea
Outcome results
None listed