Vitiligo
Conditions
Keywords
early localized vitiligo
Brief summary
Assessing the level of circulating TCMs (cluster of differentiation (CD) 8+, CD3+,C- chemokine receptor (CCR)7, cluster of differentiation 45 receptor (CD45R) cells) in early localized vitiligo cases prior to treatment and after treatment in comparison to healthy controls. This, in turn, would provide insights regarding the role of TCMs in vitiligo and the role of early treatment in halting disease progression and autoimmune memory formation that accounts for high recurrence rate of vitiligo
Detailed description
Assessing the level of circulating TCMs (CD8+ CD3+ CCR7+ CD45RO+ cells) in early localized vitiligo cases where samples will be processed and stained for CD8, CD3, CCR7, . CCR7, CD45R. Multi-parametric flow cytometry will be used to quantify CD3+ve, CD8+ve, CCR7+ve, CD45RO+ve TCM cells percentage, which will be expressed as a percentage from the total lymphocyte gate. This will be done prior to treatment and after treatment and will be compared to healthy controls.
Interventions
DRUGoral mini pulse
5mg / week oral dexamethasone
DRUGTopical cream
topical fluticasone cream for body lesions and topical tacrolimus for face lesions
DEVICEtargeted phototherapy
twice weekly targeted excimer light sessions
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
12 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
\- Subjects with vitiligo localized to one anatomical area, of ≤ 6 months' duration
Exclusion criteria
* Patients who received treatment of any type (topical or systemic) within the last 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| comparing level of circulating central memory T cells (TCM) in early localized vitiligo cases to healthy controls | 6 months | comparing TCM levels in early localized vitiligo cases prior to and after treatment to healthy controls |
| percent change in the level of circulating central memory T cells (TCM) in early localized vitiligo cases after treatment | 6 months | assessing the level of circulating central memory T cells (TCM) in early localized vitiligo cases after treatment and calculating percent change in their levels |
| comparing percent change in the level of circulating central memory T cells (TCM) in early localized vitiligo cases after treatment in those receiving systemic treatment to those receiving only topical treatment | 6 months | assessing the level of circulating central memory T cells (TCM) in early localized vitiligo cases after treatment and calculating percent change in their levels in those receiving systemic treatment to those receiving only topical treatment |
Countries
Egypt
Outcome results
None listed