Cardiac Surgery, Coronary Artery Bypass Graft, Surgical Aortic Valve Replacement
Conditions
Keywords
autonomic nervous system, heart rate variability, cardiac surgery, major morbidities
Brief summary
The hypothesis under the study is that there could be a link between a dysfunction in peripheral microcirculation, sublingual microcirculation or cardiovascular control and the development of post cardiac surgery major morbidities (stroke, acute kidney injury, prolonged intubation, mediastinitis, surgical reopening, death). The state of sublingual microcirculation, of peripheral microcirculation and cardiovascular control will be assessed in 100 patients undergoing cardiac surgery during general anesthesia before the intervention and at the end of the intervention at the arrival in post-surgery ICU by means of signal processing techniques. The extracted markers will be used to assess a statistical prediction model of major morbidities.
Interventions
DIAGNOSTIC_TESTAcquisition of cardiovascular signals and microcirculation sidestream darkfield images
ECG, arterial pressure and peripheral flow velocity via a percutaneous laser doppler will be acquired together with images of the sublingual microcirculation detected with sidestream darkfield images microscope
Sponsors
IRCCS Policlinico S. Donato
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \>18 yrs * indication for a cardiac surgery intervention * spontaneous sinus rhythm * informed consent
Exclusion criteria
* know autonomic nervous systems pathologies or dysfunctions * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prediction of major morbidities by means of the variability of cardiovascular and hemodynamics markers | 24 months | Statistical model assessment; time series variability analysis |
Countries
Italy
Outcome results
None listed