Association Between Periodontitis and the Level of Anti-citrullinated Protein Antibodies in Rheumatoid Arthritis

Association Between Severity of Periodontitis and the Level of Anti-citrullinated Protein Antibodies (ACPAs) in Rheumatoid Arthritis Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05706493

Enrollment

Registered

2023-01-31

Start date

2024-03-01

Completion date

2025-02-01

Last updated

2026-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Diseases, Rheumatoid Arthritis

Keywords

periodontitis, rheumatoid arthritis, anti citrullinated protein antibodies, peptidyl arginine deminase enzyme, gingival crevicular fluid (GCF)

Brief summary

Detailed description

the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics. The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients Materials and Methods: a total of 62 participants suffering from periodontitis and rheumatoid arthritis will be referred from the Badr Hospital (Faculty of Medicine, Helwan University) to Misr international university's dental clinic complex. Gingival crevicular fluid (GCF) samples will be collected from the patients . Assessment of ACPAs will be quantified using enzyme-linked immunoassay (ELISA) as the primary outcome Assessment of 2ry outcomes includes clinical periodontal and RA parameters

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Rheumatoid patients fulfilling the ACR criteria for the classification of RA * 18 years * Both genders * Presence of at least 8 teeth

Exclusion criteria

* Smoking * Diabetes Mellitus * Pregnant females * Patients who had undergone periodontal treatment within last 3 months * Antibiotic therapy during last 3 months * Other autoimmune diseases

Design outcomes

Primary

Measure	Time frame	Description
the level of anti-citrullinated protein antibodies (ACPAs)	Baseline	assessment of the level of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid

Secondary

Measure	Time frame	Description
Clinical attachment Loss	Baseline	measuring the distance from the cemento enamel junction to the base of the pocket in mm
Probing depth	Baseline	measuring the distance from the gingival margin to the base of the pocket in mm

Countries

Egypt

Contacts

PRINCIPAL_INVESTIGATORZainab Hafez, Lecturer

Lecturer, faculty of oral and dental medicine misr international university

PRINCIPAL_INVESTIGATORYahia Hassan, Lecturer