Aminophylline, Pain, Ureterocopic Lithotripsy
Conditions
Keywords
Aminophylline, Postoperative Pain, Ureterocopic Lithotripsy
Brief summary
This study will be conducted to evaluate the effect of intraoperative systemic aminophylline infusion on pain intensity in patients undergoing ureteroscopic lithotripsy surgeries with ureteric stent placement at the end of the procedure.
Interventions
Patients will receive 4 mg/kg aminophylline diluted in 100 ml normal saline over 20 minutes after induction of anesthesia and positioning of patients in lithotomy position.
OTHERControl group
Patients will receive 100 ml normal saline over 20 minutes after induction and lithotomy positioning.
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Aged between 18 to 50 years * American society of anesthesiology (ASA) physical status I - II * Body mass index (BMI) less than 30.0 kg/m2 * Scheduled for ureteroscopic lithotripsy surgery with D-J ureteric stent placement at the end of procedure * Under general anesthesia.
Exclusion criteria
1. Patients with central nervous system diseases, cardiovascular diseases, arrhythmias, cerebrovascular diseases, convulsions, renal impairment or hepatic dysfunction. 2. Pregnancy or lactation. 3. Patients with a history of allergy to aminophylline. 4. Coffee consumption (more than 2 cups/day) 5. Patients with opioid addiction or patients treated with B agonists, tranquilizers, or antidepressants. 6. Short procedures less than 30 minutes or procedures not requiring D-J stent placement.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intensity of pain | In post anesthesia care unit (PACU) | Visual analogue score (VAS) score: will be measured on arrival to PACU, at 30 minutes, 1 hour, 2 hour, 6, 12 and 24 hour after surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intensity of pain | 24 hour after surgery | Visual analogue score (VAS) score: will be measured on arrival to PACU, at 30 minutes, 1 hour, 2 hour, 6, 12 and 24 hour after surgery. |
| Total amount of opioid dose | 24 hour after surgery | If Patients reported VAS score more than 3, they will receive intravenous 0.5 mg /kg pethidine. All patients will be observed in PACU for at least 2 hour and in the ward on the day of surgery for confirming any side effects or complications. |
| The incidence of postoperative adverse reactions | 24 hour after surgery | the incidence of adverse reactions, such as arrhythmia, postoperative nausea and vomiting (PONV) and postoperative lightheadedness will be recorded in both groups. |
Countries
Egypt
Outcome results
None listed