Colorectal Cancer, Crohn Disease, Indeterminate Colitis, Inflammatory Bowel Diseases, Ulcerative Colitis
Conditions
Keywords
Microbiota, inflammatory bowel disease, Crohn's disease, ulcerative colitis, colorectal cancer, post-operative cognitive disorders, mood disorders, immune system.
Brief summary
Constitution of a biobank of tissues, whole blood and plasma samples and stools to identify markers associated with treatment response, postoperative morbidity including neuro-cognitive and mood complications and prognosis of Inflammatory Bowel disease or colorectal cancer.
Detailed description
Inflammatory Bowel disease (Crohn, Ulcerative colitis) and colorectal cancer are frequent affections and the microbiota plays a major role in their physiopathology involving the immune system. In this setting, the interplay between gut microbiota and brain is still unexplored. To evaluate the interaction of the microbiota and the immune system with the host in these two chronic diseases, we aim to create a prospective biobank. A small amount of tissue will be taken during surgery. A whole blood, plasma and stoll samples will also be taken from the patient. All samples will be anonymized.
Interventions
None listed
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Ulcerative colitis, Crohn's disease or colorectal disease * Digestive resection with useless tissue available * Information consent signed
Exclusion criteria
\- Patients \< 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relation between biological parameters and outcomes of digestive disease (IBD, CRC) | up to 12 months after the incusion | identify relations between serumon response to treatment, postoperative outcomes including neuro-cognitive and mood complications and prognosis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Relation between biological parameters and outcomes of digestive disease (IBD, CRC) | up to 12 months after the incusion | identify relations between plasma on response to treatment, postoperative outcomes including neuro-cognitive and mood complications and prognosis. |
| Exploratory study on the physiopathology of host-microbiota interactions to determinate the occurrence of intestinal and extra-intestinal complications | up to two months after the incusion | genetic polymorphisms, serum markers, intestinal microbiota markers to determining the occurrence of intestinal and extra-intestinal complications |
| Exploratory study on the physiopathology of host-microbiota interactions to determinate the response to treatments | up to two months after the incusion | genetic polymorphisms, serum markers, intestinal microbiota markers determining : response to treatments |
| Exploratory study on the physiopathology of host-microbiota interactions | up to two months after the incusion | genetic polymorphisms, serum markers, intestinal microbiota markers determining : interactions between host and microbiota |
| Brain-microbiota interaction | up to two months after the incusion | Exploring the pathophysiology of host-microbiota interactions in postoperative cognitive or behavioral changes involving inflammation pathways |
Countries
France
Contacts
Primary ContactJérémie LEFEVRE, PU-PH
Backup ContactHarry SOKOL, PU-PH
Outcome results
None listed