Chronic Pain
Conditions
Brief summary
The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.
Interventions
OTHERreward learning task
during usual follow-up patients will complete a remard learning task questionnaire. This questionnaire cannot be assimilated to a clinical intervention.
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin. * For controls: matched to a case on age (±5 years) and sex
Exclusion criteria
* Neurodegenerative or inflammatory neurological pathology * Clinical depressive syndrome * High doses of opioid treatment (greater than 100 mg/day of morphine equivalent) * Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks * Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population | Day 0 | the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score. |
Countries
France
Outcome results
None listed