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Prevalence of Cardiac Amyloidosis in Patients Undergoing Surgery for Lumbar Spinal Stenosis.

Prevalence of Cardiac Amyloidosis in Patients Undergoing Surgery for Lumbar Spinal Stenosis.

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05701397
Acronym
CASS-II
Enrollment
200
Registered
2023-01-27
Start date
2023-01-01
Completion date
2024-04-01
Last updated
2023-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Amyloidosis, Spinal Stenosis

Brief summary

Patients undergoing surgery for lumbar spinal stenosis will have biopsies of the ligamentum flavum sent to the department of pathology for histologic screening. If the ligament biopsy contains amyloid, patients will receive an echocardiogram, an ecg, biomarker testing, and a bone tracer scintigraphy diagnostic of cardiac amyloidosis.

Interventions

DIAGNOSTIC_TESTDPD scintigraphy

Bone tracer scintigraphy, diagnostic for transthyretin cardiac amyloidsis

Sponsors

Steen Hvitfeldt Poulsen
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Scheduled for surgery for lumbar spinal stenosis * Age \> 65 years * Informed written consent

Exclusion criteria

* Known amyloidosis * Myelomatosis * Monoclonal gammopathy of unknown significance, MGUS * Morbus Waldenstrøm

Design outcomes

Primary

MeasureTime frameDescription
Diagnosis of cardiac amyloidosis1 yearDPD scintigraphy with a Perugini Grade 2 og higher.

Countries

Denmark

Contacts

Primary ContactBertil Ladefoged
berlad@rm.dk40927245

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026