Ketosis
Conditions
Brief summary
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet. Blood ketones can be used as a source of energy during fasting and are used by your brain as an alternative source of fuel to glucose. Previous studies have found that ketones, when consumed in form of a supplement drink, can increase blood ketone levels and lower blood glucose, the amount of sugar in your blood. This is of potential interest for individuals with high blood sugar, such as people living with type 2 diabetes. However, how ketone supplements impact metabolism is not fully understood but using high throughput analysis techniques that can characterize hundreds to thousands of metabolites in the blood (known as metabolomics) may allow researchers to discover novel compounds within the body that are altered by ketone supplements. This will improve our understanding of how ketones impact metabolism and guide future research.
Interventions
DIETARY_SUPPLEMENT(R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester
Participants will consume a ketone monoester drink (0.75 k/kg body mass) with venous blood samples obtained before and after (30, 60 and 90 minutes) drink consumption.
Sponsors
Stanford University
University of British Columbia
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Single-arm pilot study
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* over the age of 18 years * able to fast overnight
Exclusion criteria
* being a competitive endurance athlete * following a ketogenic diet, low-calorie diet, periodic fasting regimen, or regular consuming ketone supplements * being unable to travel to and from the university * being pregnant or planning to become pregnant during the study * having been diagnosed with a chronic disorder of glucose or fat metabolism, including type 2 diabetes, chronic pancreatitis, or gallbladder disease * being unable to read or communicate in English
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Beta-hydroxybutyrate-derived metabolites | 90 minutes | Metabolites derived from the enzymatic conjugation of beta-hydroxybutyrate to amino acids |
Countries
Canada
Outcome results
None listed