Amyloid Cardiomyopathy, Block, AV
Conditions
Brief summary
The investigators will nationally investigate the prevalence of Transthyretin Amyloidosis wildtype (ATTRwt) in patients of ≥ 65 years with left ventricular hypertrophy who present with high degree atrioventricular block (AV-block) and are admitted for pacemaker implantation. The investigators aim to characterize the group of patients with positive screening of ATTR and compare the ATTRwt disease stage at time of diagnosis for patients identified with ATTR at screening with a control group of routinely clinically diagnosed ATTRwt patients.
Interventions
DIAGNOSTIC_TESTAmyloidosis screening (bloodtest, DPD-scintigraphy, potentially endomyocardial biopsy)
Bloodtest: Troponin I, NT-pro-BNP, electrolyte status, renal function, kampda/lambda free chain + ratio, M-komponent. DPD-scintigraphy. (Echocardiography)
Sponsors
Steen Hvitfeldt Poulsen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Men ≥65years or women ≥75years with unexplained AV-block with pacemaker indication, as decided per treating physician and presence of left ventricular hypertrophy ≥12mm.
Exclusion criteria
* Reversible causes for AV-block, som as AV-node disturbing medicament, ion-disturbances, hypothyroidism, hypoxia, ischemia, new heart surgery \<1month, endocarditis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnosis of ATTRwt in study cohort. | 3 years | Number of participants with a diagnosis of ATTRwt in the study cohort based on DPD-scintigraphy or if necessary, a cardiac biopsy. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of heart-failure associated hospitalization among ATTRwt patients | 5 years | — |
| All-cause mortality among ATTRwt patients. | 5 year | — |
| Clinical Stage of time of diagnosis in patients with ATTRwt | 3 years | Gilmore Staging |
| Characteristics of patients with ATTRwt | 3 years | Echocardiographic (Left ventricular (LV) wall thickness, LV cavity dimension, EF, GLS, diastolic function, Right Ventricular (RV) systolic function, valve disease) Biochemical profile (Troponin I, NT-pro-BNP, Renal Function (E-GFR) ), presence or history of spinal stenosis, carpal tunnel syndrome |
Countries
Denmark
Contacts
Primary ContactJens Skov, MD
Backup ContactSteen Poulsen, MD
Outcome results
None listed