Allergy, Food Allergy
Conditions
Brief summary
The objectives of this study are (i) to evaluate the efficacy of oral immunotherapy to pistachio by evaluating the daily oral tolerance of 2g pistachio, by evaluating the long-term tolerance of 15g pistachio (sustained unresponsiveness) and by decreasing pistachio-specific IgE, (ii) evaluating the efficacy of pistachio immunotherapy on cashew tolerance, (iii) and to evaluate the safety of pistachio immunotherapy.
Interventions
OTHERFood allergy
Oral immunotherapy to pistachio
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients under 18 years of age with a proven allergy to pistachio and followed in the pediatric allergology unit of the Nancy University Hospital. * Patients who have received oral immunotherapy to pistachio for at least 18 months at 31/12/2022
Exclusion criteria
* Patients who have received oral immunotherapy to pistachio for less than 18 months. * Patients lost to follow-up for more than 2 years or last consultation dating from 2020 or earlier
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Absence of moderate to severe allergic reactions | during the 6 months of maintenance | with daily intake of 2g of pistachio |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency and severity of allergic reactions | during the dose escalation phase and during the maintenance phase (first 6 months, 1st year, 2nd year, 3rd year) | — |
| Decrease in specific IgE and increase of IGg4 to pistachio | during the dose escalation phase and during the maintenance phase (first 6 months, 1st year, 2nd year, 3rd year) | — |
| Tolerance of 1, 2, 4, 8g in isolated doses and 15 g in total cumulative dose of pistachio | 3 months after stopping daily consumption of 2g pistachio | during an oral pistachio challenge test |
| Tolerance of 1, 2, 4, 8g in isolated doses and 15 g in total cumulative dose of cashew nut | 3 months after stopping daily consumption of 2g pistachio | during an oral cashew nut challenge test |
| Reactogenic or tolerogenic threshold of cashew nuts | during the dose escalation phase and during the maintenance phase (first 6 months, 1st year, 2nd year, 3rd year) | — |
Countries
France
Outcome results
None listed