Bladder Cancer
Conditions
Brief summary
miRNAs have been detected in different bodily fluids, which suggests significant potential, such as their use as biomarkers in diagnostics and prognostics. Sha-mir-71a was abundantly found in the urine of patients with bladder cancer as compared to benign bladder cystitis associated with schistosomiasis . Additionally, this miRNA was more highly detected in urine samples from patients with bilharzial bladder cancer than bladder cancer not associated with bilharziasis (schistosomiasis), suggesting its specificity in the identification of bladder cancer associated with infection.
Interventions
DIAGNOSTIC_TESTurinary micro RNA detection
Urinary Sha-miR-71a gene expression analysis Total RNA extraction and purification Sha-miR\_71a gene expression analysis MAPK-3 gene expression analysis
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* urinary symptoms (hematuria, urinary retention, dysuria… etc.), who were planned to undergo cystoscopy for suspicion of bladder cancer (BC) or benign bilharzial cystitis (Bil), will be selected.
Exclusion criteria
* : In bladder cancer group Patients who have received chemotherapy, or with previously diagnosed other malignancy within the past 5 years.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| use micro RNAas adiagnostic test for early diagnosis of shistosomal bladder cancer | one year | Sha-mir-71a could be a biomarker with diagnostic and prognostic value |
Contacts
Primary Contactesraa o ali, assistant lecturer
Backup Contacthanaa a hady, professor
Outcome results
None listed