Coronary Artery Disease, Heart Failure
Conditions
Keywords
cardiac rehabilitation, resistance training, strength training, exercise for older adults
Brief summary
Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen uptake (Peak Vo2) and leg strength (assessed Isokinetic). The investigators hypothesize that resistance training exercise with induced a high stress metabolic is more important exercise with induced than a lower stress metabolic.
Interventions
OTHER3/7 Resistance Training Method
3/7 Resistance Training Method
OTHER3X9 Resistance Training Method
3X9 Resistance Training Method
Sponsors
Université Libre de Bruxelles
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical Coronary artery diseases * Heart failure with reduced ejection fraction
Exclusion criteria
* angina * acutely decompensated heart failure * electrocardiographic evidence of ischemia * significant valvular disease * orthopedic/neurologic disorders that limited exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Peak VO2 after 3 months | Baseline and 3 months | Change in Peak oxygen consumption (VO2) after three 3 months intervention |
| Change in strength knee extensor after 3 months | Baseline and 3 months | Change in strength knee extensor (60°/sec) after three months intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in VE/VCO2 slope after 3 months | Baseline and 3 months | Change in ventilatory efficiency (VE/VCO2) slope at baseline and 3 months intervention |
| Change in submaximal exercise capacity after 3 months | Baseline and 3 months | Submaximal exercise capacity will be measured using watts at the first ventilatory threshold (VT1) |
| Change in workload maximal after 3 months | Baseline and 3 months | Change in workload max at baseline and 3 months intervention |
| Change in Body fat after 3 months | Baseline and 3 months | Change in Body fat at baseline and 3 months intervention |
| Change in lean mass after 3 months | Baseline and 3 months | Change in lean mass at baseline and 3 months intervention |
| Change in Visceral adipose tissue after 3 months | Baseline and 3 months | Change in Visceral adipose tissue measure by Dual-energy X- ray absorptiometry (DEXA) at baseline and 3 months intervention |
| Change in hand grip force after 3 months | Baseline and 3 months | Change in hand grip force on non dominant hand at baseline and 3 months intervention |
| Change in ventilation metaboreflex function after 3 months | Baseline and 3 months | Change in ventilation during metaboreflex test at baseline and 3 months intervention (Briefly, the subject is asked to exercise with the non-dominant arm by performing two 5 min handgrip manoeu- vres reaching approximately 50% of pre-determined maximal con- traction, in random order, separated by a 30 min interval: one bout with circulatory occlusion during the last 10 s of exercise and the all 3 min recovery phase ('clamp session'). During the clamp session, forearm cuff inflation to 30 mmHg above systolic blood pressure from the last 10 s of exercise till the end of the 3 min recovery phase; after cuff inflation, the subject is instructed to relax. Ergore- ceptor sensitivity is quantified as the percentage of the ventilatory and haemodynamic response to exercise maintained by circulatory occlusion during the third minute compared with the third minute of basal recovery.) |
| Change in diastolic blood pressure metaboreflex function after 3 months | Baseline and 3 months | Change in diastolic blood pressure during metaboreflex test at baseline and 3 months intervention |
| Change in leg lean mass after 3 months | Baseline and 3 months | Change in leg lean mass at baseline and 3 months intervention |
| Change in resting heart rate variability at rest after 3 months | Baseline and 3 months | Change in resting heart rate variability at baseline and 3 months intervention |
| Change 30 s sit-to-stand after 3 months | Baseline and 3 months | Change 30 s sit-to-stand at baseline and 3 months intervention |
| Change in isometric strength knee extensor after 3 months | Baseline and 3 months | Change in strength knee extensor (isometric) at baseline and 3 months intervention |
| Change in 120°/sec strength knee extensor after 3 months | Baseline and 3 months | Change in strength knee extensor (120°/sec) at baseline and 3 months intervention |
| Change in 180°/sec strength knee extensor after 3 months | Baseline and 3 months | Change in strength knee extensor (180°/sec) at baseline and 3 months intervention |
| Change strength knee extensor in leg extension after 3 months | Baseline and 3 months | Change in one repetition maximal in leg extensor machine at baseline and 3 months intervention |
| Change in sub maximal strength knee extensor in leg extension after 3 months | Baseline and 3 months | Change in 10 repetitions maximal in leg extensor machine at baseline and 3 months intervention |
| Change in heart rate recovery after 3 months | Baseline and 3 months | Change in heart rate recovery at baseline and 3 months intervention |
| Change in heart rate at rest after 3 months | Baseline and 3 months | Change in heart rate at baseline and 3 months intervention |
| Change in bone mass after 3 months | Baseline and 3 months | Change in bone mass at baseline and 3 months intervention |
Countries
Belgium
Outcome results
None listed