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Cutaneous Squamous Cell Carcinoma Staging Study

Comparison of the Prognostic Capacity of Existing Staging Systems for Cutaneous Squamous Cell Carcinoma

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05695222
Enrollment
1500
Registered
2023-01-23
Start date
2023-05-01
Completion date
2028-06-05
Last updated
2026-04-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cutaneous Squamous Cell Carcinoma

Brief summary

Cutaneous squamous cell carcinoma (CSCC) is the second most common form of skin cancer, and one of the most common cancers worldwide. The majority of CSCCs are easily removed by surgery and have excellent prognosis. However, a small subset has poor outcomes, including secondary spread in the body (metastasis) and death. The investigators will look at existing CSCC in people from two UK dermatology centres. The investigators will then evaluate the accuracy of current staging systems in predicting risk of poor outcomes in people. The investigators hope that this project will improve the management of patients with CSCC by validating the predictive power of currently available histological staging classifications for cSCC. In the second stage of the study, The investigators will see whether better prediction tools can be found.

Interventions

This is not an interventional study

Sponsors

Queen Mary University of London
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 120 Years
Healthy volunteers
Yes

Inclusion criteria

* Over 18 years old with diagnosis of CSCC

Exclusion criteria

* Patients who decline for their data to be used for research purposes

Design outcomes

Primary

MeasureTime frameDescription
Recurrence or metastasis4 yearsProportion of patients developing cutaneous squamous cell carcinoma locoregional recurrence, nodal or distant metastases

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 3, 2026