Gastrointestinal Cancer
Conditions
Brief summary
This research is for patients who have gastrointestinal cancer and have a planned major surgery. The purpose of this research is to identify cancer patients who may be at risk for frailty. Frailty is common in older adults and may include symptoms of weight loss, weakness, fatigue, low activity, slow walking and other illnesses. Frailty may increase the risk of problems after major surgery. The study will involve a survey, a blood sample, and a review of medical records.
Detailed description
The goals of the study are to: * Describe the rate of frailty in surgical cancer patients * Assess if frailty correlates with problems (adverse outcomes) after major surgery Participants taking part will be asked to complete a survey to assess frailty before surgery. The frailty survey is referred to as the Clinical Risk Analysis Index (RAI-C). Participants will have about 10 ml (2 teaspoons) of blood drawn before surgery. Blood tests will include complete blood count (CBC), vitamin A, creatinine, C-Reactive Protein (CRP), DHEA, albumin, and prealbumin.
Interventions
OTHERFrailty survey
Frailty survey using the Clinical Risk Analysis Index (RAI-C).
Sponsors
The Guthrie Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18 years old or older * histologically proven gastrointestinal malignancy * referral for elective major surgical procedures at including operations for upper and lower gastrointestinal malignancies and hepato-pancreato-biliary * referral for neoadjuvant treatment followed by any of the above major surgical procedures
Exclusion criteria
* under 18 years * pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percent of patients considered frail assessed by Clinical Risk Analysis Index (RAI-C) Scores of 21 or higher | pre-operative | Assess Clinical Risk Analysis Index (RAI-C) Scores in rural patients referred for major abdominal surgeries. Survey values will be added to yield a final RAI-C score between 0 and 81. Percent of patients considered frail will be defined as Clinical Risk Analysis Index (RAI-C) Scores of 21 or higher |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adverse outcomes after major surgery | 30 days post-operative | Assess adverse outcomes postoperatively and if their is a correlation with the frailty score |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORRebekah Macfie, MD
The Guthrie Clinic
Outcome results
None listed