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Acute Cerebrovascular Events in Patients Undergoing Catheter Ablation

Acute Cerebrovascular Events in Patients Undergoing Catheter Ablation (CENTRAL): an Investigator-initiated, Multicenter Real-world Study

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05694273
Acronym
CENTRAL
Enrollment
2000
Registered
2023-01-23
Start date
2025-01-15
Completion date
2026-12-31
Last updated
2024-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Cerebrovascular Disease, Arrhythmia

Keywords

Catheter ablation, Arrhythmia, Major adverse cardiovascular and cerebrovascular events (MACCE)

Brief summary

This study aims to evaluate the incidence, clinical characteristics, and short-term prognosis of acute cerebrovascular events occurring in-hospital in patients with arrhythmias following catheter ablation. The goal is to provide evidence supporting the improvement of patient quality of life and reduction of in-hospital acute cerebrovascular complications in patients with post-ablation arrhythmias. This will also contribute to the evidence-based clinical management of such patients.

Detailed description

With the steady development of catheter ablation, it has gradually become the main treatment of various arrhythmias. Antithrombotic and anticoagulant therapy after catheter ablation determines the occurrence of perioperative bleeding and ischemic events. However, the incidence, characteristics and short-term prognosis of secondary acute cerebrovascular events in patients with arrhythmia after catheter ablation have not been studied. Methods: This study was intended to retrospectively collect and analyze the case data and auxiliary examination results of patients with arrhythmia who underwent catheter ablation. To evaluate the incidence, clinical features and short-term prognosis of secondary acute ischemic and hemorrhagic cerebrovascular events in patients with arrhythmia after catheter ablation. In order to improve the quality of life of patients, reduce the secondary acute cerebrovascular complications in the hospital in patients with arrhythmia after catheter ablation, to provide evidence for promoting the clinical management of such patients, and to provide help for the maximum degree of prevention and control risk.

Interventions

None listed

Sponsors

Shaanxi Provincial People's Hospital
CollaboratorOTHER
521 Hospital of NORINCO Group
CollaboratorOTHER
Xiangyang Central Hospital
CollaboratorOTHER
Ankang Central Hospital
CollaboratorOTHER
Baoji Central Hospital
CollaboratorOTHER
Luoyang Central Hospital
CollaboratorOTHER
Tianjin Medical University Second Hospital
CollaboratorOTHER
Fu Wai Hospital, Beijing, China
CollaboratorOTHER
Fuwai Yunnan Cardiovascular Hospital
CollaboratorOTHER
Chinese Academy of Medical Sciences, Fuwai Hospital
CollaboratorOTHER
First Affiliated Hospital Xi'an Jiaotong University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* 1.Patients who undergo catheter ablation for arrhythmias.

Exclusion criteria

* 1\. Patients were diagnosed of acute cerebrovascular disease prior to radiofrequency catheter ablation; * 2\. Patients \< 18 years or \> 80 years; * 3\. Patients with uncomplete clinical data.

Design outcomes

Primary

MeasureTime frameDescription
Incidence of MACCE3 months after enrollmentMajor adverse cardiovascular and cerebrovascular events, a composite of all-cause mortality, myocardial infarction and stroke. The data will be obtained at 3-month follow-up, according to medical records of all patients.

Secondary

MeasureTime frameDescription
Incidence of all-cause mortality3 months after enrollmentThe data will be obtained at 3-month follow-up, according to medical records of all patients.
Incidence of myocardial infarction3 months after enrollmentThe data will be obtained at 3-month follow-up, according to medical records of all patients.
Incidence of stroke3 months after enrollmentThe data will be obtained at 3-month follow-up, according to medical records of all patients.

Countries

China

Contacts

Primary ContactGuoliang li
liguoliang_med@163.com+8613759982523

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026