GastroIntestinal Cancer in Children and Adolescents

GastroIntestinal Cancer in Children and Adolescents (GICCA): a SEER Population-based Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05693519

Acronym

GICCA

Enrollment

2500

Registered

2023-01-23

Start date

2022-12-22

Completion date

2023-06-22

Last updated

2023-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burkitt Lymphoma, Colorectal Cancer, Gastric Cancer, Gastrointestinal Cancer, Hepatoblastoma, Hepatocellular Carcinoma, Neuroendocrine Tumors

Keywords

SEER, Gastrointestinal, Cancer, Malignant, Child, Pediatric, Adolescent

Brief summary

The goal of this observational population-based cohort study is to investigate the clinical characteristics and outcomes of children and adolescents with primary gastrointestinal malignancies registered in the publicly available Surveillance, Epidemiology, and End Results (SEER) 17 database during 2000-2019.

Detailed description

The investigators aim to describe the patient and tumor characteristics, treatments, and outcomes of children and adolescents diagnosed with primary gastrointestinal malignancies, and to analyze these data for trends over time. In addition, the investigators want to explore independent prognostic factors for overall survival. Finally, the investigators want to describe subsequent primary malignancies diagnosed among patients from the study cohort, as well as to calculate their risk of developing a second primary cancer relative to the general population. Data on children (aged 0-17 years at diagnosis) and young people aged 18-24 years at diagnosis are analyzed separately. Special focus is laid on patients with primary carcinomas of the gastrointestinal tract; particularly colorectal carcinoma.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

0 Years to 24 Years

Healthy volunteers

Inclusion criteria

* Age at primary gastrointestinal cancer diagnosis \<25 years * Diagnosis of a primary gastrointestinal malignancy as an individual's first primary malignancy

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
Overall survival	2000-2019	Defined as the time between the date of diagnosis and the date of death from any cause (event) or date of last follow-up.

Secondary

Measure	Time frame	Description
Standardized incidence of second primary malignancies	2000-2019	Standardized incidence of second primary malignancies in patients who survived (i) two or more months, or (ii) five or more years after initial gastrointestinal cancer diagnosis, relative to the general population.

Countries

Netherlands

Outcome results