Cardiovascular Diseases, Preterm Birth
Conditions
Brief summary
Preterm birth is associated with maternal increased risk of cardiovascular disease later in life. In an observational case- control study, investigators want to evaluate whether women with preterm birth have increased levels of biomarkers for cardiovascular disease, to reveal potential pathophysiological mechanisms in common.
Detailed description
Women with spontaneous preterm birth in first pregnancy and a group of matched controls with spontaneous birth in normal time where invited to participate in the study. Participants were identified from the Biobank of Pregnant Women in Uppsala. Levels of cardiovascular biomarkers will be analyzed in plasma samples from the pregnancy and at a follow-up visit where investigators also collect information about other cardiovascular risk factors and lipid status.
Interventions
OTHERNo intervention
No intervention
Sponsors
Uppsala University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 60 Years
Healthy volunteers
No
Inclusion criteria
* Women identified as cases or controls
Exclusion criteria
* System inflammatory disease * Smoking at the time of the pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Levels of Factor XII in plasma in women with preterm birth in compared to a control group with delivery in normal time. | spring 2023 | Levels of Factor XII in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. |
| Levels of complement C5 in women with preterm birth in compared to a control group with delivery in normal time. | spring 2023 | Levels of complement C5 in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. |
| Levels of apolipoprotein M in women with preterm birth in compared to a control group with delivery in normal time. | spring 2023 | Levels of apolipoprotein M in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. |
| Levels of fibrinogen in women with preterm birth in compared to a control group with delivery in normal time. | spring 2023 | Levels of fibrinogen in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. |
| Levels of plasma kallikrein in women with preterm birth in compared to a control group with delivery in normal time. | spring 2023 | Levels of plasma kallikrein in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. |
| Levels of vitamin D binding protein in women with preterm birth in compared to a control group with delivery in normal time. | spring 2023 | Levels of vitamin D binding protein in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. |
| Levels of cadherin -5 in women with preterm birth in compared to a control group with delivery in normal time. | spring 2023 | Levels of cadherin -5 in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. |
| Levels of growth/differentiation Factor-15 (GDF-15) in women with preterm birth in compared to a control group with delivery in normal time. preterm birth compared to a control group with delivery in normal time. | spring 2023 | Levels of growth/differentiation Factor-15 (GDF-15) in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. |
Countries
Sweden
Outcome results
None listed