Acquired Myopathy, Congenital Myopathy, Myositis
Conditions
Keywords
Muscle disease
Brief summary
This study aims to determine the association between the pathological changes detected by ultrasound and those detected in MRI in muscle diseases of different etiologies.
Detailed description
Enrolled patients will be subjected to the following: Neuro-imaging Studies: 1. Skeletal Muscle ultrasound: The muscle group(s) to be assessed will be determined based on the category of the muscle disease for which the patient is being evaluated. A linear probe of 5-12 megahertz will be used. 2. MRI of the suspected (affected) muscle group by ultrasound. Image acquisition: Selective regional MRI imaging will be done based on the results of muscle ultrasound MRI cuts included are the axial section of conventional T1- and T2-weighted sequences, for the evaluation of muscles' signal intensity and bulk. Patients will be subjected to both imaging studies to compare their accuracy. Neurophysiological Studies: 1. Nerve conduction study 2. Electromyogram The interpretation of the neurophysiological studies will be performed by a neuropsychiatry specialist, Department of Neurology, Assiut University Hospital.
Interventions
DEVICEMRI
MRI will be employed to assess muscle composition, evidence of degeneration or replacement by fat
Sponsors
Assiut University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. A clinical diagnosis of muscle diseases; irrespective of different etiologies 2. Age \> 3 years
Exclusion criteria
1. Patients with altered muscle anatomy due to severe trauma, tumor or surgery. 2. Severe deformity preventing examination. 3. Age \< 3years. 4. Patients with contraindications to MRI as patients with pacemaker, aneurysmal clipping, retained metallic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of abnormal ultrasound and Magnetic resonance studies separately | through study completion, an average of 1 year | Abnormal Magnetic resonance study: muscle fat replacement (qualitatively through T1 weighted images, and qualitatively through Mercuric visual grading system), edema ( T2 relaxation time mapping), fibrosis ( magnetic resonance elastography) Abnormal muscle ultrasound study (replacement of healthy muscle with fat and fibrosis, manifested by an increase in echogenicity, visual method based on evaluating echogenicity in relation to other structures and semi-quantitatively) |
| Association between the results of Skeletal muscle ultrasound (normal vs. abnormal) and the results of MRI (normal vs. abnormal study) | within 6 months after recruitment ends (Recruitment completion is anticipated In Sep 2023) | — |
| Association between the individual abnormalities detected by skeletal muscle ultrasound and those detected by MRI. | within 6 months after recruitment ends (Recruitment completion is anticipated In Sep 2023) | — |
| Diagnostic accuracy of each modality in reference to the clinical and neurophysiological diagnosis and muscle biopsy. | within 6 months after recruitment ends (Recruitment completion is anticipated In Sep 2023) | — |
Contacts
Primary ContactTayseer MH Hamza, resident
Backup ContactTayseer MH Hamza, resident
Outcome results
None listed