Anomalous Aortic Origin of Coronary Artery

Anomalous Aortic Origin of Coronary Artery: From Pathophysiology to Risk Stratification Through a Patient Specific Computational Simulation Model

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05692063

Acronym

AAOCA

Enrollment

130

Registered

2023-01-20

Start date

2019-06-27

Completion date

2024-06-30

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anomalous Aortic Origin of the Coronary Artery (AAOCA)

Brief summary

This project has several objectives ranging from clinical data analysis to computational simulations as listed below: A) Clinical objectives: 1. Retrospective review of all patients with AAOCA treated surgically and followed medically at the IRCCS Policlinico San Donato aiming to identify risk factors for ischemia or sudden cardiac deaths. 2. Prospective follow-up of all enrolled patients, treated and followed, in adjunct to all the new patients referred aiming to follow across the years any potential rare adverse event (ischemia, angina event, sudden cardiac death). B) Experimental objectives: 1. Retrieve morphological measurements from CT or MRI (de-identified) of the aortic root and the coronary vessels following the previous work of our group. 2. Construct a parametric model of the aortic root defined by population-based morphologic parameters to describe both healthy/diseased population. 3. Run solid mechanics simulation mimicking the movement of the aortic root in order to test configurations at more risk. 4. Reconstruct 3D surfaces representing the coronary vasculature from imaging for automatically perform the parameter estimation and run computational fluid dynamics simulations.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* All patients (adults and pediatrics) who have been diagnosed with an anomalous aortic origin of any of the coronary arteries (AAOCA) without any other congenital heart disease and diagnosed/referred or followed at the IRCCS Policlinico San Donato.

Exclusion criteria

* Patients with other major congenital heart disease with associated coronary artery origin anomalies will be excluded. Patients with anomalous origin of the coronary artery from the pulmonary artery (ALCAPA or ARCAPA) will be excluded. Patients women who are pregnant.

Design outcomes

Primary

Measure	Time frame	Description
ischemia, angina event, sudden cardiac death	10 years	2\. Creation of a prospective registry in which will be enrolled all patients already treated and followed in adjunct to all the new patients referred aiming to follow across the years any potential rare adverse event

Secondary

Measure	Time frame	Description
risk factors for ischemia or sudden cardiac deaths	10 years	1\. Retrospective review of all patients with AAOCA treated surgically and followed medically at the IRCCS Policlinico San Donato aiming to identify risk factors for ischemia or sudden cardiac deaths.

Countries

Italy

Outcome results