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Regional Blocks for CABG Artery Bypass Graft Surgery

Ultrasound Guided External Oblique Intercostal Plane Block and Pectointercostal Plane Block for Perioperative Analgesia in Coronary Artery Bypass Graft Surgery: Prospective Randomized Controlled Study

Status
UNKNOWN
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05691920
Enrollment
120
Registered
2023-01-20
Start date
2023-02-01
Completion date
2023-07-01
Last updated
2023-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia After Coronary Artery Bypass Graft Surgery

Brief summary

Pain control after CABG is an essential step to guard against postoperative complications such as lung atelectasis. This major step can be achieved by opioids or regional blocks. Regional blocks allow better pain control and avoid side effects of opioid based pain control

Detailed description

Ultrasound guided External oblique intercostal plane block and pectointercostal plane block for perioperative analgesia in coronary artery bypass graft surgery: Prospective randomized controlled study Introduction: Pain control is a vital component to achieve enhanced recovery after cardiac surgery. Effective postoperative pain control will reduce the incidence of numerous postoperative complications, can facilitate early mobilization and may result in earlier recovery. Pain control is historically achieved by the administration of opioids, which is associated with well-documented side effects, such as sedation, respiratory depression, pruritus, hallucinations and postoperative nausea and vomiting (PONV). Enhanced recovery following coronary artery bypass grafting (CABG) has gained attention even though there is limited evidence on the efficacy and effectiveness of existing analgesic techniques. The external oblique intercostal plane and pectointercostal plane blocks are a new modality that will be used to improve pain-related outcomes after CABG surgery, and has not been extensively investigated. Therefore, we will test the hypothesis that external oblique intercostal plane and pectointercostal plane blocks can reduce cumulative opioid consumption for the patients undergoing CABG surgery when added to conventional multi-model intravenous analgesic technique. The aim of this prospective comparative investigation is to assess the impact of external oblique intercostal plane and pectointercostal plane blocks in a multimodal perioperative analgesic regimen and any related side effects in patients undergoing CABG surgery. Patients and Methods: A prospective study will be carried out in Alexandria Main University Hospital on 120 American society of anaesthesiologists (ASA) II, III physical status aged 40-60 years scheduled for major upper abdominal surgery, after approval of the Medical Ethics Committee and an informed written consent. Patients will be categorized into two equal groups, group I (60) will be subjected to bilateral external oblique intercostal plane and pectointercostal plane blocks and group II (60) will be subjected to fentanyl infusion at a rate of 1μg/kg/h. During the patient stay in the ICU, total analgesic requirements will be measured in both groups. Also, sedation level, duration of intubation and length of ICU stay will be assessed.

Interventions

PROCEDUREPectointercostal plane block and external oblique intercostal plane block

Patients will be subjected to bilateral external oblique intercostal plane and pectointercostal plane blocks

Patients will be subjected to fentanyl infusion at a rate of 1μg/kg/h

Sponsors

Alexandria University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Masking description

Double blinded

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* patients undergoing CABG surgery

Exclusion criteria

* BMI above 40 * allergy for drugs used * complicated cases * patient refusal * chronic opioid use * cognitive dysfunction * chronic kidney disease

Design outcomes

Primary

MeasureTime frameDescription
Postoperative fentanyl requirements for 24 hours24 hours postoperativelyVisual analogue score will be measured every 2 hours

Secondary

MeasureTime frameDescription
Visual analogue score24 hours postoperativelyVisual analogue score will be measured every 2 hours
Rescue analgesia24 hours postoperatively0.5 microgram/kg fentanyl will be given if visual analogue score more than 4
Side effects24 hours postoperativelyAny side effect related to fentanyl or block technique will be detected and treated properly

Contacts

Primary ContactMohamed Abdelmawla, MD
M_abdelmawla12@alexmed.edu.eg+201114748411
Backup ContactMaha Ghanem, MD
Ghanemmaha@yahoo.com+20127498435

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026