Endothelial Dysfunction, Periodontal Diseases
Conditions
Brief summary
An association between periodontitis and endothelial dysfunction has been reported, suggesting that periodontitis presents an inflammatory burden to the cardiovascular system, that might lead to AVD. The study aims aim to assess whether non-surgical periodontal therapy enhances endothelial function in periodontitis patients using a non-invasive diagnostic device to assess endothelial function through PWA and the assessment of levels of salivary Endothelin-1, in a population of people in the UAE.
Interventions
DIAGNOSTIC_TESTAssessment of pulse wave amplitude (PWA)
Assessment of pulse wave amplitude (PWA) through peripheral arterial tonometry (PAT) using the device EndoPAT (Itamar Medical)
DIAGNOSTIC_TESTSalivary Nitric Oxide
assessment the levels of salivary Nitric Oxide using a Nitric Oxide colorimetric detection kit,
Sponsors
University of Sharjah
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Group 1: periodontally healthy subjects. * Group 2: patients with periodontitis stage III or IV and grades A,B or C.
Exclusion criteria
* Medical conditions: Diabetes,pregnancy,obesity,renal disease,patients with cardiovascular diseases including hypertension,recent myocardial infarction or unstable angina (within 3 months),congestive heart failure,valvular heart disease * Heavy smokers(\>10 cigarettes per day), * Regular administration of drugs resulting in gingival hyperplasia,root planning in the past 6 months * Regular administration of drugs resulting in gingival hyperplasia (such as cyclosporine and phenytoin) * Recent antibiotic use (in the past 3 months) * Non-surgical periodontal therapy in the past 6 monthsp
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pulse wave amplitude | 2 months |
Countries
United Arab Emirates
Contacts
Primary ContactZahi BADRAN, PhD
Outcome results
None listed