Idiopathic Membranous Nephropathy
Conditions
Brief summary
Infection is one of common risk factors for relapsing of idiopathic membranous nephropathy (IMN). However, it is still unclear wheather COVID-19 infection can induce the relapsing of IMN. Herein, in this prospective, multi-center, cohort study, the investigator enrolled the IMN patients with COVID-19 infection. All subjects will be followed for three months with four visits at 1, 2 and 3 months. Then the investigator will compare the rate of replase of IMN in the two groups to evaluate the association of COVID-19 infection and replapse of IMN.
Interventions
None listed
Sponsors
Beijing Pinggu District Hospital
Beijing Fangshan District Liangxiang Hospital
Beijing Friendship Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
1. the status of nephrotic syndrome is complete remmision or partial remmision; 2. estimated glomerular filtration rate (eGFR according to the CKD-EPI formula) ≥60 mL/min per 1.73 m2; 3. patients with a moderate risk of IMN.
Exclusion criteria
1. secondary causes of MN; 2. the labarotary data two months before enrolement is absent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| primary outcome | 3 months | relaspe of nephrotic syndrome: proteinuria\<0.3g/d, serum albumin\>30g/l, serum creatitine below 111 μmol/l |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| secondary outcome | 0.5, 1, and 2 months | relaspe of nephrotic syndrome: proteinuria\<3.5g/d (decreased over 50% of baseline), serum albumin\>30g/l, steady serum creatitine (fluctuated less than 20% of baseline), meet the above criteria over 2 times |
Countries
China
Contacts
Primary ContactZongli Diao, Dr.
Outcome results
None listed