Crystalline Lens Tilt Evaluation Using Swept-source Optical Coherence Tomography

Evaluation of the Physiological Crystalline Lens Tilt Using Longitudinal and High-resolution Swept-source Optical Coherence Tomography: a Retrospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05690893

Acronym

PhysTilt

Enrollment

1000

Registered

2023-01-19

Start date

2023-02-01

Completion date

2023-06-30

Last updated

2023-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract Surgery

Keywords

Cataract, CASIA2, IOL Master700

Brief summary

The goal of this retrospective study is to quantify the physiological lens tilt of the phakic eye. The main question it aims to answer is: -What influence does misalignment or tilting of IOLs have on visual quality? Preoperative biometry data are compared with anterior segement OCT data. Measurements were obtained using high-resolution swept-source optical coherence tomography. The influence of biometric measurements on tilt is analyzed.

Detailed description

The human (crystalline or phakic) lens is located in the capsular bag which is attached to zonules. Zonules are fibres, that hold the lens in place. In the course of life, an opacification on the lens occurs, which is called cataract. To replace the cloudy lens, cataract surgery is being performed and an artificial intraocular lens (IOL) is implanted in the eye, after the phakic lens is removed. Misalignment or tilting of IOLs can result in reduction of visual quality, therefore prediction of the position may be beneficial. Modern optical coherence tomography (OCT) devices already provide profound information about phakic lens tilt. Still there is little data on the values that influence the tilt of the crystalline lens. Before each cataract surgery, each eye is measured using biometry (IOL Master 700). However, a statement about the tilt cannot be made on the basis of the results of IOL Master 700. For this purpose, an anterior segment OCT is required (CASIA 2). In this study, preoperative biometry data are compared with anterior segment OCT data. A statistical analysis will then be performed to identify the biometric parameters that can predict phakic lens tilt.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to 100 Years

Healthy volunteers

Inclusion criteria

* Planned cataract surgery in one or both eyes * Minimum age of 21 years

Exclusion criteria

* Opacities of the refracting media * Measurement error in the context of preliminary investigation * pseudophakia

Design outcomes

Primary

Measure	Time frame	Description
Physiological lens tilt	June 2020 - October 2022	SS-OCT measurements (IOLMaster700 and Casia2) to investigate axial eye length, anterior chamber depth and lens thickness and their influence on lens tilt

Secondary

Measure	Time frame	Description
Correlation of biometric data	June 2020 - October 2022	Correlation of other biometric data (lens thickness, anterior chamber depth, white-to-white) with lens tilt

Countries

Austria

Outcome results