Coagulation Tests
Conditions
Brief summary
The main objective is to study the effect of engineered nanoparticles SPIONs (superparamagnetic iron oxide) on hemostasis. Nanoparticles will be incubated in blood and platelet aggregation will be measured. In parallel, nanoparticles will also be incubated in blood and then plasma proteins adsorbed on them will be separated and analyzed. The proteins found on the nanoparticles will be linked to the platelet aggregation observed to help developing innovative protein functionalized nanoprobes for optimized nanomedicine.
Interventions
OTHERblood tests
evaluate the possible impact of iron oxide nanoparticles (superparamagnetic iron oxide = SPIONs) (N=10) in the blood circulation;
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 79 Years
Inclusion criteria
* all people
Exclusion criteria
* patient under 18 years old, legal protection measure, pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| impact of nanoparticles on coagulation tests ou platelet functions | at the baseline |
Secondary
| Measure | Time frame |
|---|---|
| Difference of behaviour of the nanoparticles (N=10 preparations) on coagulation cascade and platelet functions | at the baseline |
Countries
France
Contacts
Primary ContactDE MAISTRE Emmanuel
Outcome results
None listed