Tumor, Brain, Tumor, Breast, Tumor Skin
Conditions
Keywords
intraoperative assessment, whole-mount H&E staining, surgical border assessment
Brief summary
The goal of this clinical trial is to develop an imaging platform for intraoperative tumor margin delineation in 250 cases of tumor-suffered patients. The main questions it aims to answer are: • to develop the protocol of rapid assessment of surgical specimens without need for fixation, embedding, and cryosectioning required for conventional histopathology. Participants will provide a small piece of their surgical specimens from tumor removal surgery . If there is a comparison group: Researchers will compare normal specimens to see if we can observe the difference.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Patients who are more than 20 years old. 2. Diagnosed as patients suffered by skin tumor, brain tumor and breast tumor.
Exclusion criteria
1. Patients who can't speak and communicate with others. 2. Patients who can't make eventual and exact pathological assessment for his/her diseases. 3. Patients who only can fit for slicing tumor. 4. Removed tissues which obviously vary after severe ray radiation under microscopy observation. 5. Diameter of tumors are under 1 centimeter. 6. Breast carcinoma in situ.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The assessment between tumor cases and control cases | 5 years | Do comparison with images acquired by our microscopy (with the whole-mount staining method) and bright field microscopy (with standard FFPE method) and do assessment to interpret tumor characteristics |
Countries
Taiwan
Contacts
Primary ContactYi-Hua YH Liao, PhD
Backup ContactYao-Chen YC Tseng, Master
Outcome results
None listed