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Head Elevation During Pre-oxygenation Can Delay Desaturation Time

Head Elevation During Pre-oxygenation Can Delay Desaturation Time in Indonesian Patients

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05688722
Enrollment
56
Registered
2023-01-18
Start date
2021-04-01
Completion date
2021-05-31
Last updated
2023-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Apnea, Desaturation of Blood, Surgery

Keywords

preoxygenation, head elevation, desaturation, apnea

Brief summary

This study is a randomized-controlled trial study comparing the association between several degree of head elevation and conventional position during pre-oxygenation to desaturation time in patients undergo endotracheal intubation with general anesthesia

Detailed description

Preoxygenation anesthesia induction is an important part of airway management to reduce the risk of hypoxemia when the patient is apneic. The effectivity of preoxygenation is influenced by several things such as patient's head position. This study aimed to compare preoxygenation with head elevation 20°, 30° and 45° and conventional position to the time of desaturation before endotracheal intubation in patients undergoing general anesthesia. This was a randomized clinical trial of 56 patients, divided into four groups (conventional or 0° head elevation group, 20° head elevation group, 30° head elevation and 45° head elevation group). All subject was preoxygenated for 3 minutes with 100% oxygen. Induction of anesthesia was started with fentanyl, propofol, followed by rocuronium after the patient lost consciousness. Time was recorded from the start of induction until the oxygen saturation showed 93% or a time limit of 5 minutes. There was a significant difference in mean desaturation time among the four groups (p = 0.011). The most significant different was in 45o head elevation group (p \< 0.05). . In patients undergoing general anesthesia, pre-oxygenation with head elevation 20°, 30° and 45° slows down the time for desaturation before endotracheal intubation compared to the conventional position. The 45° head elevation has the best result.

Interventions

PROCEDURESupine position

Patients preoxygenated in supine position before endotracheal intubation

PROCEDURE20 degree head elevation position

Patients preoxygenated in 20 degree head elevation position before endotracheal intubation

PROCEDURE30 degree head elevation position

Patients preoxygenated in 30 degree head elevation position before endotracheal intubation

PROCEDURE45 degree head elevation position

Patients preoxygenated in 45 degree head elevation position before endotracheal intubation

Sponsors

Indonesia University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Masking description

The care provider and investigator were not blinded.

Intervention model description

Patients were divided into 4 groups by random sampling each with different intervention

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

* undergo endotracheal intubation with general anesthesia for elective surgery * aged 18-60 years old * ASA physical status 1-2 preoperatively

Exclusion criteria

* Patients with difficult airway, cardiopulmonary disease, anemia, grade II obesity, pregnant, history of hypersensitivity to induction agents * Patients did not give consent to follow the study

Design outcomes

Primary

MeasureTime frameDescription
Desaturation timeRight after induction until reach oxygen saturation 93% or 5 minutes time limitTime was recorded from the start of induction until the oxygen saturation showed 93% or a time limit of 5 minutes

Countries

Indonesia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026