Glottic Web of Larynx, Laryngeal Stenosis, Glottic Carcinoma, Laryngeal Leucoplakia, Laryngeal Polyp, Laryngeal Papilloma
Conditions
Keywords
Curcumin
Brief summary
To provide a novel therapy idea and method to solve the clinical problem of postoperative adhesion of bilateral vocal cords, patients enrolled in this study will be applied with curcumin on both wound sites of bilateral vocal cords after the surgery on the bilateral vocal cord endoscopically.
Interventions
DRUGCurcumin
Curcumin was applied to both wound sites of bilateral vocal cords. After evenly applied, gently massage the applied site for 3-5 minutes until the drug was fully absorbed.
DRUGMitomycin-C
Mitomycin-C was applied to both wound sites of bilateral vocal cords. After evenly applied, gently massage the applied site for 3-5 minutes until the drug was fully absorbed.
Sponsors
Eye & ENT Hospital of Fudan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Patients with bilateral vocal cord diseases who are going to undergo resection of bilateral vocal cord lesions endoscopically. 2. Patients with bilateral vocal cord adhesion who are going to undergo incision of bilateral vocal cord adhesion endoscopically.
Exclusion criteria
1. Patients with other laryngeal diseases. 2. Patients with cardiac and pulmonary insufficiency. 3. Patients unable to cooperate with the follow-up on time after surgery. 4. Patients who refuse to sign the informed consent after notification. 5. Patients who have a severe allergic disease or allergic history to a variety of drugs. 6. Other circumstances that are not appropriate to be included in the clinical trial.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with laryngeal web formation as assessed by videolaryngoscope | 1 year postsurgery | All participants received the videolaryngoscope every month post-surgery, and a laryngeal web is defined as a visible adhesion whose length reached 1 mm or greater. |
Countries
China
Contacts
Primary ContactJian Chen, Ph.D
Backup ContactHaitao Wu, Ph.D
Outcome results
None listed