Intracerebral Hemorrhage
Conditions
Keywords
Intracerebral Hemorrhage, Apolipoprotein E gene, Perihematomal edema, Outcome
Brief summary
The purpose of this observational study was to compare perihematomal edema and short-term prognosis in patients with intracerebral hemorrhage carrying the APOE-ε3 and APOE-ε4 genes. The main questions it aims to answer are: * Exploring whether patients carrying the ApoE-ε4 gene have more perifocal perihematomal edema after intracerebral hemorrhage than patients with the ApoE-ε3 gene. * ApoEε4 gene has worse short-term prognosis than ApoEε3 gene in intracerebral hemorrhage patients. All the patients in this study received the same medications based on the guidelines for the management of hypertensive intracerebral hemorrhage.Some ICH patients were evaluated for Stereotactic minimally invasive surgery (sMIS) treatment by two experienced neurosurgeons.
Interventions
DIAGNOSTIC_TESTNon-enhanced CT scan、Nuclear Magnetic Resonance (MRI)
Non-surgical patients were followed up by CT on days 1 and 5-7 after ICH, and by CT or MRI on day 5-7. Surgical patients were followed up by CT before surgery and then transferred to the operating room. The first postoperative follow-up CT scan was performed on the second day after surgery, and the second postoperative CT scan was performed on the third day after surgery. Some patients need a third or even a fourth CT follow-up after surgery. The CT scan can be repeated at any time if the patient has neurologic deterioration.
Sponsors
The Affiliated Hospital Of Guizhou Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Relevant diagnosis of supratentorial ICH was confirmed through unenhanced CT scanning. * Patients were distinguished based on venous blood collection, with the presence of the ApoE-ε4 (ε2/ε4, ε3/ε4, ε4/ε4) gene (ApoE-ε4 genotype) and patients harboring the ApoE-ε3 (ε3/ε3) gene (non-ApoE-ε4 genotype).
Exclusion criteria
* Patients with infratentorial ICH. * Patients with ApoE-ε2 (ε2/ε2) based on venous blood collections. * Younger than 18 years of age. * ICH caused by trauma, anticoagulation therapy, or antiplatelet therapy. * Patients admitted to the hospital with diseases that might impact inflammatory responses, such as infective meningitis and systemic infections. * Patients with previous residual neurological deficits following a stroke. * Patients with combined tumours, severe liver and kidney dysfunction, cardiac insufficiency.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| One month after ICH | A maximum of 1 month was assessed from the date of randomization to the date of the first record of progression or death from any cause, whichever came first. | Telephone follow-up by experienced neurologist.Defining a modified Rankin Scale (mRS) score of 0-3 at discharge was considered to be a good prognosis. If the mRS score was \>3, the prognosis was considered poor. |
| Volume of perihematoma edema | Within 24 hours of ICH | Calculation of perihematoma edema volume after ICH by non-enhanced CT scan. |
| Changes in the volume of perihematoma edema | Days 5-7 after ICH | Calculation of perihematoma edema volume after ICH by non-enhanced CT scan. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Venous blood indicators | Within 24 hours of the onset of ICH | Indicators of venous blood leukocytes, neutrophils and blood lymphocytes (10\^9/L) were analysed. |
Countries
China
Outcome results
None listed