Bacteremia, Infection, Bacterial, Infection, Fungal
Conditions
Keywords
intensive care unit, blood culture, prediction, score
Brief summary
Prospective observational cohort consisting of all adult patients admitted to participating critical care units (ICU and CCU) during the study period, with blood cultures collected as part of their care, and who did not express any objection to participating. For each patient, data will be collected prospectively for each blood culture set collected.
Interventions
OTHERno intervention
no intervention
Sponsors
University Hospital, Tours
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female, age 18 years or older * Patient admitted to an ICU or ICU * patient with a blood culture sample as part of care
Exclusion criteria
* Patient already included in this study during a previous hospitalisation * Opposition expressed for participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the ROC curve of the predictive performance of the score for predicting bacteremia or fungemia. | day 1- day 28 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Area under the ROC curve of the diagnostic performance of the Shapiro score for predicting bacteremia or fungemia; | day 1- day 28 | — |
| Proportion of bacteremia or fungemia identified by blood cultures in patients on antibiotic therapy and broad-spectrum antibiotic therapy, and factors associated with these bacteremias or fungemias; | day 1- day 28 | — |
| Area under the ROC curve of the diagnostic performance of body temperature to predict bacteremia or fungemia; | day 1- day 28 | — |
| Descriptive study of the contribution of blood cultures, whatever their results, to the prescription of anti-infectives. | day 1- day 28 | — |
| Efficiency of the new predictive score for blood culture positivity in Intensive Care, as compared with body temperature and Shapiro score, measured by two Incremental Cost-Effectiveness Ratios (ICER): ICER (incremental cost per additional well-detecte | less than 1 month | A tree decision model will compare three strategies for predicting positive blood cultures: the new predictive score, body temperature and Shapiro score. Within-trial data will be used to define the model parameters. The model will consider the costs related to the implementation of the strategies, blood cultures, and potential delays in patient management. This will result in the estimation of the two ICERs. |
| Comparison of the diagnostic performance of the score in predicting bacteremia or fungemia observed during the first 48 hours of hospitalization to later bacteremias; | 48 hours | — |
Countries
France
Outcome results
None listed