Corona Virus Infection, Surgery
Conditions
Keywords
Lung cancer, Surgery, Corona Virus Infection
Brief summary
The goal of this observational study is to learn about the effects of coronavirus infection in patients with early-stage lung cancer. The main question it aims to answer is whether the interval of surgery and COVID-19 infection will affect the surgery and prognosis of the patients.
Interventions
OTHERNo intervention
Observational study, no intervention
Sponsors
Ruijin Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinically diagnosed stage I and stage II lung cancer, who are about to receive wedge resection, segmental resection, sleeve resection, lobectomy, or pneumonectomy under general anaesthesia. * Volunteer to participate in the study with good compliance. Able to complete the observation and follow-up and have signed the informed consent. * ASA score: I-III; * Cardiopulmonary functions meet the requirements of radical operation for lung cancer with normal liver and kidney functions.
Exclusion criteria
* Neurologic, mental illness or mental disorder which is hard to control, poor compliance, unable to cooperate or describe the treatment response; * Clinically diagnosed stage III and stage IV lung cancer or patients who received neoadjuvant treatment before surgery; * Patients developed symptoms alike coronavirus infection but are not confirmed by viral RNA detection by quantitative RT-PCR or antigen testing kits. * Serious heart, lung, liver and kidney dysfunction and unable to tolerate the operation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative morbidity | postoperative in-hospital stay up to 30 days | rate of perioperative complications, mainly include: pneumonia, respiratory failure, pulmonary embolism, arrhythmia, sepsis, cerebrovascular accident, myocardial injury, acute kidney injury. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| operation time | At operation day | duration of operation |
| R0 rate | postoperative in-hospital stay up to 30 days | R0 resection rate |
| postoperative hospital stay | postoperative in-hospital stay up to 30 days | length of postoperative hospitalization |
| 30-day mortality | postoperative in-hospital stay up to 30 days | 30-day mortality after surgery |
| quality of life | postoperative in-hospital stay up to 30 days | postoperative quality of life |
| blood loss | At operation day | blood loss in the operation |
Countries
China
Outcome results
None listed