Ischemic Stroke
Conditions
Brief summary
The aim of this study is to analyze the relationship between the blood biomarker GDF-15 and heart damage after stroke. It is being conducted in France, in the Neurology Department of the Dijon University Hospital (Burgundy). The research is interventional because a biological blood test will be performed, as well as a heart rhythm recording and several cardiac echograms during the hospitalization of the participants and during the follow-up consultation scheduled 4 to 6 months after the stroke. A total of 130 stroke patients will participate in this study. Participation includes 4 visits: * Inclusion visit (within 24 hours of the first stroke symptoms) * visit 1 (within 24 to 72 hours of stroke) * visit 2 (within 48 hours of visit 1) * Visit 3 (approximately 4-6 months post-stroke)
Interventions
PROCEDUREElectrocardiogram
Inclusion visit, V1, V2 and V3
PROCEDUREtransthoracic echocardiography
V1, V2 and V3
BIOLOGICALstandard biology
Inclusion visit
BIOLOGICALdetermination of serum GDF-15, osteoprotegerin and ST-2
Inclusion visit, V1, V2 and V3
BIOLOGICALUltrasensitive Troponin-Ic
Inclusion visit, V1, V2 and V3
OTHERCollection of clinical and radiological data
Inclusion visit, V1 and V3: clinical data only V2: clinical and radiological data
OTHER72-hour continuous Holter-ECG recording
V1
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult with acute symptomatic cerebral infarction documented by brain imaging on admission (cerebral angioscan or cerebral MRI) * Whose first symptoms appeared within 24 hours before inclusion * Whose consent to participate in this study was obtained from the patient or a close relative.
Exclusion criteria
* Person with a history of symptomatic stroke, either ischemic or hemorrhagic * Anyone with a history of heart disease including: atrial fibrillation or flutter (known or discovered on admission), chronic heart failure, pacemaker, defibrillator, or other cardiac devices * Person with acute heart failure, suspected infective endocarditis, STEMI, or concurrent pulmonary embolism * A person who is not a member or beneficiary of a social security system * Person deprived of liberty * Person subject to a legal protection measure (curatorship, guardianship) * Person subject to a legal protection measure * Pregnant, parturient or breastfeeding woman
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global Longitudinal Strain (GLS) of the left ventricle measured by trans-thoracic ultrasound (TTE) | within 24 to 72 hours post-stroke |
Countries
France
Contacts
Primary ContactYannick BEJOT
Outcome results
None listed