Alopecia, Androgenetic
Conditions
Keywords
Androgenetic Alopecia, Centrifugation, Platelet-rich plasma, Thrombocyte
Brief summary
This research is a preliminary, randomized, double blind clinical trial, which will examine the differences in PRP preparation methods, a single-spin centrifugation of 3000 rpm in 15 minutes compared to a double-spin centrifugation of 1500 rpm in 6 minutes followed by 2500 rpm in 15 minutes, on the results of Thrombocyte Concentration and Clinical Improvement of Androgenetic Alopecia.
Detailed description
Several examinations will be performed in every visit, including history taking, physical examination, trichoscopy and trichoscan. Laboratory evaluations (complete blood count) for the measurement of the thrombocyte for baseline and PRP will be performed for all assented subjects on the first visit. Each subject will be instructed to apply 5% topical minoxidil twice a day everyday as primary therapy during the study
Interventions
PROCEDUREPlatelet-Rich Plasma Injections (PRP) on the Scalp
each subject will be treated with 3x PRP injections on the scalp with 2 weeks interval in addition to daily minoxidil administration.
Sponsors
Indonesia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
this is a double-blind masking study
Eligibility
Sex/Gender
MALE
Age
25 Years to 59 Years
Healthy volunteers
No
Inclusion criteria
* Met the criteria of androgenic alopecia (Hamilton Norwood grade III-IV) * Men between ages 25-59 years old * Have stopped taking topical anti-androgen or minoxidil for at least one month, or oral anti-androgen or minoxidil for at least three months
Exclusion criteria
* alopecia of any other type * subject with a history of keloid or blood coagulation disorders underwent anticoagulant therapy * subjects on Non-Steroidal Anti-Inflammatory Drugs (NSAID) medications in seven days prior to the study * subjects who had hair treatment using growth factors, including PRP and microneedling within at least six months prior to the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Thrombocyte Count in PRP and Whole Blood | 6 weeks | We assessed the increase in PRP platelet levels by assessing baseline platelets (using whole blood) and assessing platelet levels in PRP preparations and then calculating multiples. platelet valuie units to be used is (/μL) |
| Clinical Improvement of Androgenetic Alopecia | 6 weeks | We assessed the assessment of clinical improvement in androgenetic alopecia using trichoscopy and trichoscan examination on week 0, 2, 4, and 6. On trichoscopic examination we assessed hair color, hair diameter diversity, vellus hair, and dots. Whereas on trichoscan examination we assessed hair count, hair diameter (mm), hair density (/cm2), hair rate (%) in vellus hair, terminal, anagen and telogen phases and assessed hair mean thickness (mm/cm2) and mean length (mm) and average hair per unit. |
Countries
Indonesia
Outcome results
None listed