Plaque Burden and Ischemia in MINOCA

Coronary Artery Plaque, Perivascular Inflammation and Myocardial Ischemia in Patients With Myocardial Infraction and Non-obstructive Coronary Arteries

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05681858

Enrollment

100

Registered

2023-01-12

Start date

2023-08-15

Completion date

2027-08-31

Last updated

2023-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MINOCA

Brief summary

The goal of this clinical trial is to assess coronary artery plaque burden, perivascular inflammation and extent of myocardial ischemia in patients presenting with acute myocardial infarction and non-obstructive coronary artery disease. The main question it aims to answer are: * Identify coronary artery anatomy, plaque burden, composition and high-risk plaque features by CT coronary angiography in MINOCA * Assess presence, extent and severity of myocardial ischemia in MINOCA Participants will examined by CT coronary angiography and stress \[12N\] NH3 PET-MR.

Interventions

DIAGNOSTIC_TESTCT coronary angiography and [12N] NH3 PET-MR

Advanced coronary artery plaque analysis, myocardial ischemia and coronary flow reserve

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Acute chest pain * Elevated troponin * Non-obstructive coronary arteries by coronary angiography

Exclusion criteria

* Obstructive coronary artery disease * Contraindications against CT coronary angiography or stress \[12N\] NH3 PET-MR * Not able to give informed consent

Design outcomes

Primary

Measure	Time frame
Plaque burden	1 week
Myocardial ischemia	1 week

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026