Epicardial Adipose Tissue and Arterial Stiffness in People Living With Diabetes (METAB-CV-PWV)

Tissu Adipeux épicardique et rigidité artérielle Chez Les Personnes Vivant Avec un diabète

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05681533

Acronym

METAB-CV-PWV

Enrollment

400

Registered

2023-01-12

Start date

2021-03-31

Completion date

2023-03-31

Last updated

2023-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Patients

Keywords

Diabet, arterial stiffness, pericardial adipose tissue

Brief summary

The present study is a retrospective and prospective current care cohort that will allow us to evaluate the relationship between epicardial fat volume and increased arterial stiffness in a person living with diabetes.

Detailed description

Epicardial adipose tissue is considered as the cardiac visceral fat and is associated with increased cardiovascular risk, for example in diabetes. Thus, the mechanisms involved seem to be related to myocardial lipotoxicity; atherosclerosis in connection with inflammation and secretion of proinflammatory factors such as cytokines but also insulin resistance. In this context, the investigators hypothesize that epicardiac adipose tissue volume will be higher in patients with increased arterial stiffness than in those without. In this study, the investigators will then try to verify the existence of a relationship between pericardial adipose tissue volume and increased arterial stiffness in people living with diabetes. To do this, the investigators will analyze the results of measurements of pericardial fat volume, coronary calcium score, and pulse wave velocity in diabetic patients.

Interventions

PROCEDURECT scan

coronary calcium score measurement by CT scan

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients will be eligible for participation in the study if: * They are informed and have not objected to participating in the research. * They have type 1 or 2 diabetes. * They perform a coronary calcium score measurement by CT scan and a pulse wave velocity assessment during their routine care practice.

Design outcomes

Primary

Measure	Time frame	Description
Epicardial fat volume	the inclusion visit	Epicardial fat volume will be determined using cardiac CT scan without contrast injection.

Countries

France

Contacts

Primary ContactEmmanuel COSSON, Pr

emmanuel.cosson@aphp.fr01 48 95 51 54

Backup ContactOmar NOUHOU KOUTCHA, Dr

omarnouhou1@gmail.com07 64 18 07 14

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026