Endometriosis, Infertility Unexplained
Conditions
Brief summary
The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis. The study included women with unexplained infertility and clinical picture suggestive of presence of endometriosis were divided randomly into two groups: Control and study groups. All patients underwent exploratory laparotomy for diagnosis and grading of endometriosis if present. Patients of study group gave blood samples for estimation of plasma expression levels of microRNA 203 and 210 using qRT-PCR procedure.
Interventions
PROCEDURELaparoscopic Exploration
Laparoscopic Exploration to diagnose & grade endometriosis
DIAGNOSTIC_TESTEstimation of Plasma Expression level of MICRO RNA 203 & 210
estimation of Plasma Expression level for GeneMicro RNA 203 & 210 by qRT-PCR
Sponsors
Benha University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* 30-45 years old * Unexplained infertility
Exclusion criteria
* Presence of other causes of infertility, * age out of the predetermined range, * the presence of immune disorders, * maintenance on immunosuppressive drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| grading of endometriosis | 8 months | The diagnostic performance of estimated plasma levels of microRNA for diagnosis and grading endometriosis |
Countries
Egypt
Outcome results
None listed