Atorvastatin Antihypertensive Effect
Conditions
Brief summary
This study is aimed to see the antihypertensive effect of statin (Atorvastatin) as certain animal models have shown that statins have the voltage-gated calcium channel blocking effect. It will be a randomized controlled trial that will be done in Ayub Hospital Complex Abbottabad. After ethical approval, 120 patients with newly diagnosed hypertension belonging to either gender and aged 35 and above will be enrolled in the trial. They will randomly be grouped into two groups with each group comprising 60 patients. One group will be administered Amlodipine 5 mg PO once a day, while the other one will be given 5mg Amlodipine plus 10 mg Atorvastatin. The patients will be examined on a follow-up visit 14 days later and blood pressure will be recorded as per protocols.
Interventions
DRUGAmlodipine 5 MG Oral Tablet
one group will be given only Amlodipine 5MG once daily
DRUGAmlodipine 5 MG / Atorvastatin 10 MG Oral Tablet
one group will be given Amlodipine 5mg plus Atorvastatin 10MG once daily
Sponsors
Ayub Teaching Hospital
Khyber Medical University Peshawar
Himayat Ullah
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- The inclusion criteria for the study were all newly diagnosed hypertensive patients aged 35 years and above with normal lipid profile
Exclusion criteria
* Patients with a history of dyslipidemias, diabetes mellites, chronic kidney disease, and ischemic heart disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Antihypertensive effect of atorvastatin | 14 days | patients receiving atorvastatin based combination should have more decrease in the blood pressure. |
Countries
Saudi Arabia
Outcome results
None listed