Cerebral Small Vessel Diseases, ICAS - Intracranial Atherosclerosis
Conditions
Keywords
Intracranial atherosclerosis, Cerebral small vessel disease, Feedback mechanism, Multimodal MRI
Brief summary
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.
Detailed description
Cerebrovascular disease is the most common cause of death worldwide. There is a close link in structure and function between the intracranial large arteries and cerebral small vessels. Moreover, growing evidences have demonstrated that large artery atherosclerosis often coexists with small vessel disease, which may deteriorate the clinical outcomes of stroke and dementia. The mutual feedback mechanism between them is not fully understood. The present study focuses on the mechanism of mutual feedback between large artery atherosclerosis and cerebral small vessel disease by using magnetic resonance imaging. The study may provide biomarkers for the early prevention and treatment of cerebrovascular disease.
Interventions
DIAGNOSTIC_TESTMagnetic resonance imaging
Imaging diagnostics mainly based on Magnetic resonance imaging.
Sponsors
Chinese PLA General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * At least one intracranial artery ≥ 50% atherosclerotic stenosis * Modified Rankin Scale \< 2 * Mini-mental State Examination \> 24
Exclusion criteria
* Concurrent ipsilateral extracranial artery ≥ 50% stenosis * Pregnant women * Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progression in total cerebral small vessel disease burden | 1-3 YEARS | Total cerebral small vessel disease burden is assessed according to a sum of scores of white matter hyperintensity, cerebral microbleeds, lacunes and enlarged perivasular spaces on magnetic resonance imaging sequences. |
| Frequency of stroke recurrence | 1-3 YEARS | The percentage of symptomatic participants who suffer from stroke recurrence after enrollment in the territory of the targeted stenotic vessel. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of stroke of asymptomatic participants | 1-3 YEARS | The percentage of asymptomatic participants who suffer from stroke after enrollment in the territory of the targeted stenotic vessel. |
Countries
China
Contacts
Primary ContactJinhao Lyu
Outcome results
None listed