Iodine Nutrition Status, Thyroid Function
Conditions
Brief summary
The goal of this observational study is to provide a reference for formulating individual appropriate iodine intake programs for women during pregnancy and postpartum and improving the monitoring and evaluation system of maternal iodine nutrition status. The main questions it aims to answer are: * To analyse the longitudinal changes of urinary iodine, urinary iodine/creatinine ratio, thyroid function and related factors in different periods of early, middle, late pregnancy and 6 weeks postpartum in Beijing area. * To explore the relationship between iodine nutrition status and the changes of thyroid function and to further clarify the effect of iodine nutrition status on thyroid function of women of childbearing age during pregnancy and postpartum in combination with dietary intake of iodine questionnaire. Participants will be detected there thyroid function, the level of median urinary iodine and urinary iodine/creatinine. Researchers will compare healthy women of childbearing age served as the control group in the same period.
Interventions
OTHERiodine nutrition status
iodine nutrition status
Sponsors
Beijing Friendship Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
8-12 weeks healthy maternal: Inclusion Criteria: * primigravida * no chronic hypertension, thromboembolic disease, severe gastrointestinal, cardiopulmonary and liver diseases before pregnancy * no systemic lupus erythematosus, rheumatic diseases and other connective tissue diseases or immune diseases before pregnancy * no adrenocortical hyperplasia, pituitary endocrine diseases and other diseases before pregnancy
Exclusion criteria
* multiple pregnancies and multigravida * a history of type I or type II diabetes before pregnancy * a clear history of thyroid diseases before pregnancy * taking drugs that affect thyroid function and/or blood sugar before or during early pregnancy Healthy women of childbearing age: Inclusion Criteria: * 20-40 years old * no chronic hypertension, thromboembolic disease, severe gastrointestinal, cardiopulmonary and liver diseases * no systemic lupus erythematosus, rheumatic diseases and other connective tissue diseases or immune diseases * no adrenocortical hyperplasia, pituitary endocrine diseases and other diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Data of pregnant women in the early trimester of pregnancy | Any day between weeks 8 and 12 of gestation | detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary iodine and urinary iodine/creatinine |
| Data of pregnant women in the middle trimester of pregnancy | Any day between weeks 24 and 28 of gestation | detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary |
| Data of pregnant women in the third trimester of pregnancy | Any day between weeks 36 of gestation to the day before parturition | detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary |
| Data of postpartum women | 6 weeks after parturition | detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary |
Countries
China
Contacts
Primary ContactYan Long, Chief Physician/Professor
Outcome results
None listed